ArticleScientific reports2017
Superposition-free comparison and clustering of antibody binding sites: implications for the prediction of the nature of their antigen.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Humanized Anti-PD-1 Antibodies Generated Using The Conditional Kernel-Elastic Autoencoder.bioRxiv : the preprint server for biology · 2026Article
- Structure-free antibody paratope similarity prediction foriScience · 2023Article
- Binding site identification of G protein-coupled receptors through a 3D Zernike polynomials-based method: application to C. elegans olfactory receptors.Journal of computer-aided molecular design · 2022Article
- A novel computational strategy for defining the minimal protein molecular surface representation.PloS one · 2022Article
- Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Shape Complementarity Optimization of Antibody-Antigen Interfaces: The Application to SARS-CoV-2 Spike Protein.Frontiers in molecular biosciences · 2022Article
- Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces.Frontiers in molecular biosciences · 2021Article
- 2D Zernike polynomial expansion: Finding the protein-protein binding regions.Computational and structural biotechnology journal · 2021Article
- Molecular Mechanisms Behind Anti SARS-CoV-2 Action of Lactoferrin.Frontiers in molecular biosciences · 2021Article
- In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2.Frontiers in molecular biosciences · 2021Article
- Structural Insights on the SARS-CoV-2 Variants of Concern Spike Glycoprotein: A Computational Study With Possible Clinical Implications.Frontiers in genetics · 2021Article
- Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches.Biomedicines · 2020Article
- Real time structural search of the Protein Data Bank.PLoS computational biology · 2020Article
- Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions.Cells · 2020Article
- Quantitative Characterization of Binding Pockets and Binding Complementarity by Means of Zernike Descriptors.Journal of chemical information and modeling · 2020Article
- A novel strategy for molecular interfaces optimization: The case of Ferritin-Transferrin receptor interaction.Computational and structural biotechnology journal · 2020Article
- Antibody Clustering Using a Machine Learning Pipeline that Fuses Genetic, Structural, and Physicochemical Properties.Advances in experimental medicine and biology · 2020Article
- Structural Aspects of the Allergen-Antibody Interaction.Frontiers in immunology · 2020Review
- Antibody Specific B-Cell Epitope Predictions: Leveraging Information From Antibody-Antigen Protein Complexes.Frontiers in immunology · 2019Article
- Biotherapeutics: Challenges and Opportunities for Predictive Toxicology of Monoclonal Antibodies.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe here a superposition free method for comparing the surfaces of antibody binding sites based on the Zernike moments and show that they can be used to quickly compare and cluster sets of antibodies. The clusters provide information about the nature of the bound antigen that, when combined with a method for predicting the number of direct antibody antigen contacts, allows the discrimination between protein and non-protein binding antibodies with an accuracy of 76%. This is of relevance in several aspects of antibody science, for example to select the framework to be used for a combinatorial antibody library.
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