Evidence map›Paper›PMID 28337997›Full record

ArticleScientific reports2017

The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells.

Hoin Kang, Jun Gi Rho, Chongtae Kim, Hyosun Tak, Heejin Lee, Eunbyul Ji, Sojin Ahn, A-Ri Shin, Hyun-Il Cho, Yun Hyun Huh and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  12. Crucial Roles of microRNA-Mediated Autophagy in Urologic Malignancies.International journal of biological sciences · 2021
    Review
  13. Article
  14. p130Cas/Frontiers in cell and developmental biology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hoin KangDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Jun Gi RhoDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Chongtae KimDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Hyosun TakDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Heejin LeeDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Eunbyul JiDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Sojin AhnDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
A-Ri ShinCatholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, South Korea.
Hyun-Il ChoCatholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, South Korea.
Yun Hyun HuhDepartment of Life Science, Bio Imaging and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Woo Keun SongDepartment of Life Science, Bio Imaging and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Wook KimDepartment of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Eun Kyung LeeDepartment of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Catholic University of Korea · KRAjou University · KRGwangju Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.

Indexed as

Gene Expression Regulation, NeoplasticRNA Interference3' Untranslated RegionsAnimalsCell Line, TumorCell MovementCell ProliferationCrk-Associated Substrate ProteinDisease Models, AnimalGene Expression ProfilingHumansMiceMicroRNAsNeoplasm MetastasisNeoplasmsTranscriptome3' Untranslated RegionsBCAR1 protein, humanCrk-Associated Substrate ProteinMicroRNAsMIRN24 microRNA, human

Identifiers

PMID28337997
PMCPMC5364481
OpenAlexW2601639859

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.