ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2018
Lesion symptom map of cognitive-postural interference in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors - A Systematic Review and Meta-Analysis.Annals of clinical and translational neurology · 2026Pooled it
- Cognitive-Postural Interference in Multiple Sclerosis.Frontiers in neurology · 2019Pooled it
- The Relationship between Cognitive Dysfunction and Postural Stability in Multiple Sclerosis.Medicina (Kaunas, Lithuania) · 2021Trial
- Cognitive-Motor Coupling in Multiple Sclerosis: Do Chronological Age and Physical Activity Matter?Brain sciences · 2025Article
- A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis.Therapeutic advances in neurological disorders · 2025Review
- Brain and cognitive reserve mitigate balance dysfunction in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Structural and functional magnetic resonance imaging correlates of fatigue and dual-task performance in progressive multiple sclerosis.Journal of neurology · 2023Article
- The X factor in neurodegeneration.The Journal of experimental medicine · 2022Article
- Gait decline while dual-tasking is an early sign of white matter deterioration in middle-aged and older adults.Frontiers in aging neuroscience · 2022Article
- Video game therapy on mobility and dual tasking in multiple sclerosis: study protocol for a randomised controlled trial.BMJ open · 2021Article
- Dalfampridine improves slowed processing speed in multiple sclerosis patients with mild motor disability: post hoc analysis of a randomized controlled trial.Therapeutic advances in neurological disorders · 2021Article
- Spotlight on postural control in patients with multiple sclerosis.Degenerative neurological and neuromuscular disease · 2018Review
- Does the radiologically isolated syndrome exist? A dual-task cost pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Spatial distribution of white matter degenerative lesions and cognitive dysfunction in relapsing-remitting multiple sclerosis patients.Neurologia i neurochirurgia polskaArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the disease-altered structure-function relationship underlying the cognitive-postural interference (CPI) phenomenon in multiple sclerosis (MS).
methodsWe measured postural sway of 96 patients and 48 sex-/age-matched healthy controls by force platform in quiet standing (single-task (ST)) while performing the Stroop test (dual-task (DT)) to estimate the dual-task cost (DTC) of balance. In patient group, binary T2 and T1 lesion masks and their corresponding lesion volumes were obtained from magnetic resonance imaging (MRI) of brain. Normalized brain volume (NBV) was also estimated by SIENAX. Correlations between DTC and lesion location were determined by voxel-based lesion symptom mapping (VLSM) analyses.
resultsPatients had greater DTC than controls ( p < 0.001). Among whole brain MRI metrics, only T1 lesion volume correlated with DTC ( r = -0.27; p < 0.01). However, VLSM analysis did not reveal any association with DTC using T1 lesion masks. By contrast, we found clusters of T2 lesions in distinct anatomical regions (anterior and superior corona radiata, bilaterally) to be correlated with DTC ( p < 0.01 false discovery rate (FDR)-corrected). A multivariable stepwise regression model confirmed findings from VLSM analysis. NBV did not contribute to fit the model.
conclusionOur findings suggest that the CPI phenomenon in MS can be explained by disconnection along specific areas implicated in task-switching abilities and divided attention.
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