Evidence map›Paper›PMID 28337848›Full record

ReviewMacromolecular bioscience2017

Designing Smart Materials with Recombinant Proteins.

Sydney Hollingshead, Charng-Yu Lin, Julie C Liu

Abstract readReview
In one paragraph

Review in Macromolecular bioscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Smart polymers for cell therapy and precision medicine.Journal of biomedical science · 2019
    Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sydney HollingsheadDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907-2100, USA.
Charng-Yu LinDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907-2100, USA.
Julie C LiuDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907-2100, USA.

Funding

Biomimetic Scaffolds to Promote Stem Cell Differentiation for Cartilage EngineeriR21AR065644 · NIAMS · PURDUE UNIVERSITY · PI LIU, JULIE C., PANITCH, ALYSSA · 2014 to 2015
$362k
Protein-based Cartilage Matrices to Promote Mesenchymal Stem Cell DifferentiationR03DE021755 · NIDCR · PURDUE UNIVERSITY · PI LIU, JULIE C. · 2013 to 2014
$231k
NIAMS NIH HHS R21 AR065644NIDCR NIH HHS R03 DE021755
6 · The paper itself

Abstract

Recombinant protein design allows modular protein domains with different functionalities and responsive behaviors to be easily combined. Inclusion of these protein domains can enable recombinant proteins to have complex responses to their environment (e.g., temperature-triggered aggregation followed by enzyme-mediated cleavage for drug delivery or pH-triggered conformational change and self-assembly leading to structural stabilization by adjacent complementary residues). These "smart" behaviors can be tuned by amino acid identity and sequence, chemical modifications, and addition of other components. A wide variety of domains and peptides have smart behavior. This review focuses on protein designs for self-assembly or conformational changes due to stimuli such as shifts in temperature or pH.

Indexed as

Protein AggregatesAnimalsHumansProtein DomainsProtein EngineeringRecombinant ProteinsProtein AggregatesRecombinant Proteinsbiomaterialsbiopolymershydrogelsself-assemblystimuli-sensitive polymers

Identifiers

PMID28337848
PMCPMC6020822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.