Evidence map›Paper›PMID 28337664›Full record

ArticleBreast cancer research and treatment2017

Aromatase expression in atypical ductal hyperplasia in women.

R J Santen, D C Radisky, A Degnim, M H Frost, C M Vachon, K Ghosh, F Guestini, K M McNamara, H Sasano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

R J SantenUniversity of Virginia Health Sciences System, Charlottesville, VA, USA. RJS5y@virginia.edu.
D C RadiskyMayo Clinic, Jacksonville, FL, USA.
A DegnimMayo Clinic, Rochester, MN, USA.
M H FrostMayo Clinic, Rochester, MN, USA.
C M VachonMayo Clinic, Rochester, MN, USA.
K GhoshMayo Clinic, Rochester, MN, USA.
F GuestiniTohoku University School of Medicine, Sendai, Japan.
K M McNamaraTohoku University School of Medicine, Sendai, Japan.
H SasanoTohoku University School of Medicine, Sendai, Japan.
Mayo Clinic in Arizona · USTohoku University · JPUniversity of Virginia Health System · USWinnMed · US

Funding

Molecular Discriminators in Benign Breast Tissue for Future Risk of ER positive aR01CA187112 · NCI · MAYO CLINIC ROCHESTER · PI DEGNIM, AMY C · 2014 to 2018
$2.9M
Identifying high risk mammographic features in women with benign breast diseR21CA186734 · NCI · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2014 to 2015
$401k
NCI NIH HHS R01 CA187112NCI NIH HHS R21 CA186734
6 · The paper itself

Abstract

purposeTo determine the levels of aromatase in atypical ductal hyperplasia (ADH) lesions, tissue surrounding the ADH, and in dense and non-dense normal breast tissue. We postulated that excess aromatase in breast tissue might, through production of increased estrogen, drive the carcinogenic process. Estrogens and their metabolites are thought to contribute to the development of breast cancer through estrogen receptor-mediated mechanisms and genotoxic effects of estrogen metabolites. ADH is a benign lesion of the breast which is associated with substantially increased risk for subsequent development of breast cancer. After 25 years, approximately 30% of women with ADH develop breast cancer. In women with three or more separate ADH lesions at the same time, 47% will develop breast cancer over that time period. Another important risk factor for breast cancer is the presence of mammographically dense breast tissue.

methodsWe utilized quantitative immunochemical analysis of aromatase in biopsy tissue to test this possibility. Previously published results comparing dense with non-dense breast tissue in normal women (Vachon et al. Breast Cancer Res Treat 125:243-252, 2011) were used for comparisons with ADH. A well-characterized histochemical H-score was employed for quantitative assessment of aromatase in the various tissue studied.

resultsThe H-score of aromatase staining was statistically significantly higher (p = 0.003) in the ADH epithelium than surrounding epithelial tissue. In order of H-score from highest to lowest were ADH, issue surrounding ADH, dense normal and non-dense normal breast tissues. The levels of aromatase in a subset of women with ADH who went on to develop breast cancer were not higher than in women who did not.

conclusionsWe suggest from these studies that overexpression of aromatase in breast tissue and its resultant increase in estradiol levels may contribute to the later development of breast cancer in women with ADH.

Indexed as

AdultAromataseBiopsyBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedReceptors, EstrogenAromataseReceptors, EstrogenAromataseAtypical ductal hyperplasiaBreast cancerRisk factors

Identifiers

PMID28337664
PMCPMC9465997
OpenAlexW2602866267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.