Evidence map›Paper›PMID 28337463›Full record

ReviewBioMed research international2017

Skin Tissue Engineering: Application of Adipose-Derived Stem Cells.

Agnes S Klar, Jakub Zimoch, Thomas Biedermann

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03548610 (Efficacy and Safety of a Nanofat-seeded Biological Scaffold in Healing Lower Limb Surgical Defects), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03548610 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

Efficacy and Safety of a Nanofat-seeded Biological Scaffold in Healing Lower Limb Surgical Defects: A Randomized, Controlled Study

TypeinterventionalSponsorBrigham and Women's HospitalRan2019 to 2021Enrolled0ConditionsWound of Skin, Non-melanoma Skin Cancer, Skin Graft Complications, Wound of Lower LegArmsNanofat-seeded biological scaffold on surgical defect
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 107 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Isolation of Stromal Vascular Fraction by Fractionation of Adipose Tissue.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Isolation and Culture of Human Dermal Fibroblasts.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Agnes S KlarUniversity Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-3521-8010
Jakub ZimochUniversity Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Thomas BiedermannUniversity Children's Hospital Zurich, Tissue Biology Research Unit, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
University Children's Hospital Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perception of the adipose tissue has changed dramatically over the last few decades. Identification of adipose-derived stem cells (ASCs) ultimately transformed paradigm of this tissue from a passive energy depot into a promising stem cell source with properties of self-renewal and multipotential differentiation. As compared to bone marrow-derived stem cells (BMSCs), ASCs are more easily accessible and their isolation yields higher amount of stem cells. Therefore, the ASCs are of high interest for stem cell-based therapies and skin tissue engineering. Currently, freshly isolated stromal vascular fraction (SVF), which may be used directly without any expansion, was also assessed to be highly effective in treating skin radiation injuries, burns, or nonhealing wounds such as diabetic ulcers. In this paper, we review the characteristics of SVF and ASCs and the efficacy of their treatment for skin injuries and disorders.

Indexed as

Mesenchymal Stem CellsTissue EngineeringAdipocytesAdipose TissueBone Marrow CellsCell DifferentiationHumansSkinStem Cell Transplantation

Identifiers

PMID28337463
PMCPMC5350314
OpenAlexW2592627244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.