Evidence map›Paper›PMID 28337453›Full record

ArticleBioMed research international2017

miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/

Junquan Weng, Hui Zhang, Cheng Wang, Jianfeng Liang, Guanhui Chen, Wenqing Li, Haikuo Tang, Jinsong Hou

Abstract read
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Functional assessment of miR‑1291 in colon cancer cells.International journal of oncology · 2022
    Article
  8. Polysaccharides Extracted fromEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  9. Article
  10. Article
  11. Drug Discovery of DKK1 Inhibitors.Frontiers in pharmacology · 2022
    Review
  12. Review
  13. Article
  14. Review
  15. MicroRNAs as Modulators of Oral Tumorigenesis-A Focused Review.International journal of molecular sciences · 2021
    Review
  16. Article
  17. HPVTranslational oncology · 2021
    Review
  18. Activation of theInternational journal of molecular sciences · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junquan WengDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Department of Stomatology, Shenzhen People's Hospital, Second Clinical Medical School of Jinan University, Shenzhen, Guangdong 518020, China.ORCID 0000-0002-1128-2555
Hui ZhangDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Department of Stomatology, Pingshan New District People's Hospital of Shenzhen, Shenzhen, Guangdong 518118, China.
Cheng WangDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Jianfeng LiangDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Guanhui ChenDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Wenqing LiDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Haikuo TangDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Jinsong HouDepartment of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, China; Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.ORCID 0000-0003-2699-0543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) regulate gene expression and at the same time mediate tumorigenesis. miR-373-3p has diverse effects in tumors, but its role in tongue squamous cell carcinoma (TSCC) remains unknown. The purpose of this study is to determine the function of miR-373-3p in the progression of TSCC. Our results brought to light that miR-373-3p is markedly upregulated in clinical TSCC tissues compared with paired adjacent normal tissues and has significant correlation with a more aggressive TSCC phenotype in patients. Gain-of-function and loss-of-function studies revealed that ectopic miR-373-3p overexpression promoted the metastasis of TSCC cells. Notably, Wnt/

Indexed as

Carcinoma, Squamous CellCell Line, TumorEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansIntercellular Signaling Peptides and ProteinsMaleMicroRNAsNeoplasm InvasivenessNeoplasm MetastasisTongue NeoplasmsWnt Signaling PathwayDKK1 protein, humanIntercellular Signaling Peptides and ProteinsMicroRNAsMIRN373 microRNA, human

Identifiers

PMID28337453
PMCPMC5350393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.