Evidence map›Paper›PMID 28337365›Full record

ArticleJournal of gastric cancer2017

Body Composition as a Prognostic Factor of Neoadjuvant Chemotherapy Toxicity and Outcome in Patients with Locally Advanced Gastric Cancer.

Carolina Palmela, Sónia Velho, Lisa Agostinho, Francisco Branco, Marta Santos, Maria Pia Costa Santos, Maria Helena Oliveira, João Strecht, Rui Maio, Marília Cravo and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastric cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 11 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 11 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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  10. Nutritional interventions in elderly gastrointestinal cancer patients: the evidence from randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  11. Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019
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  18. Transformer-based skeletal muscle deep-learning model for survival prediction in gastric cancer patients after curative resection.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Carolina PalmelaDivision of Gastroenterology, Surgical Department, Hospital Beatriz Ângelo, Loures, Portugal .
Sónia VelhoNutrition Department, Hospital Beatriz Ângelo, Loures, Portugal .
Lisa AgostinhoRadiology Department, Hospital Beatriz Ângelo, Loures, Portugal .
Francisco BrancoOncology Department, Hospital Beatriz Ângelo, Loures, Portugal .
Marta SantosGeneral Surgery Department, Hospital Beatriz Ângelo, Loures, Portugal .
Maria Pia Costa SantosDivision of Gastroenterology, Surgical Department, Hospital Beatriz Ângelo, Loures, Portugal .
Maria Helena OliveiraPathology Department, Hospital Beatriz Ângelo, Loures, Portugal .
João StrechtRadiology Department, Hospital Beatriz Ângelo, Loures, Portugal .
Rui MaioGeneral Surgery Department, Hospital Beatriz Ângelo, Loures, Portugal .
Marília CravoDivision of Gastroenterology, Surgical Department, Hospital Beatriz Ângelo, Loures, Portugal .
Vickie E BaracosDivision of Palliative Care Medicine, Department of Oncology, Cross Cancer Institute, University of Alberta, Alberta, Canada .
Hospital Beatriz Ângelo · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeoadjuvant chemotherapy has been shown to improve survival in locally advanced gastric cancer, but it is associated with significant toxicity. Sarcopenia and sarcopenic obesity have been studied in several types of cancers and have been reported to be associated with higher chemotherapy toxicity and morbi-mortality. The aim of this study was to assess the prevalence of sarcopenia/sarcopenic obesity in patients with gastric cancer, as well as its association with chemotherapy toxicity and long-term outcomes. MATERIALS AND

methodsA retrospective analysis was performed using an academic cancer center patient cohort diagnosed with locally advanced gastric cancer between January 2012 and December 2014 and treated with neoadjuvant chemotherapy. We analyzed body composition (skeletal muscle and visceral fat index) in axial computed tomography images.

resultsA total of 48 patients met the inclusion criteria. The mean age was 68±10 years, and 33 patients (69%) were men. Dose-limiting toxicity was observed in 22 patients (46%), and treatment was terminated early owing to toxicity in 17 patients (35%). Median follow-up was 17 months. Sarcopenia and sarcopenic obesity were found at diagnosis in 23% and 10% of patients, respectively. We observed an association between termination of chemotherapy and both sarcopenia (P=0.069) and sarcopenic obesity (P=0.004). On multivariate analysis, the odds of treatment termination were higher in patients with sarcopenia (odds ratio=4.23; P=0.050). Patients with sarcopenic obesity showed lower overall survival (median survival of 6 months [95% confidence interval {CI}=3.9-8.5] vs. 25 months [95% CI=20.2-38.2]; log-rank test P=0.000).

conclusionsSarcopenia and sarcopenic obesity were associated with early termination of neoadjuvant chemotherapy in patients with gastric cancer; additionally, sarcopenic obesity was associated with poor survival.

Indexed as

Body compositionNeoadjuvant therapyPrognosisSarcopeniaStomach neoplasms

Identifiers

PMID28337365
PMCPMC5362836
OpenAlexW2596656713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.