Evidence map›Paper›PMID 28337026›Full record

ArticleInternational journal of obesity (2005)2017

Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status.

F Li, L Lu, Y Peng, Y Zhang, J Gao, D Zhou, D Zhou, H Sheng, S Qu

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

F LiDepartment of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
L LuDepartment of General Surgery, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai, China.
Y PengDepartment of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases and Shanghai Institute of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Y ZhangDepartment of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
J GaoDepartment of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
D ZhouDepartment of General Surgery, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai, China.
D ZhouDepartment of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
H ShengDepartment of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
S QuDepartment of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
Shanghai Tenth People's Hospital · CNShanghai Clinical Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-2 (GLP-2) affects multiple facets of gastrointestinal physiology and have been used to treat patients with short bowel syndrome, but the distribution of its receptor (GLP2R) in human remains poorly understood. Gastric tissue samples of non-obese patients (NOB, n=10) and obese patients without diabetes (OB, n=31) and with diabetes (OWD, n=12) were used to evaluate GLP2R expression and distribution. Immunostaining with a validated antibody, as well as fluorescence in situ hybridization, showed that GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCζ expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.

Indexed as

Gene Expression RegulationAdultChief Cells, GastricDiabetes Mellitus, Type 2Energy MetabolismFemaleGlucagon-Like Peptide-2 ReceptorHumansIn Situ Hybridization, FluorescenceMaleObesity, MorbidSignal TransductionGLP2R protein, humanGlucagon-Like Peptide-2 Receptor

Identifiers

PMID28337026
OpenAlexW2602520396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.