ArticleScientific reports2017
Expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Immunohistochemical, Immunofluorescent, and Molecular Investigation of Canine Distemper Virus, Nectin 4, and CD150 Receptors in Naturally Infected Dogs with Canine Distemper Virus.Animals : an open access journal from MDPI · 2026Article
- Characterization of the Hemagglutinin Gene ofVeterinary sciences · 2025Article
- Canine distemper outbreak and laryngeal paralysis in captive tigers (Panthera tigris).BMC veterinary research · 2025Article
- Ependymal cells: roles in central nervous system infections and therapeutic application.Journal of neuroinflammation · 2024Review
- Central Nervous System Disorders of Marine Mammals: Models for Human Disease?Pathogens (Basel, Switzerland) · 2024Review
- Extracellular vesicles: an emerging tool for wild immunology.Discovery immunology · 2024Review
- Morbillivirus: A highly adaptable viral genus.Heliyon · 2023Review
- Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein.Journal of virology · 2023Article
- Prolonged persistence of canine distemper virus RNA, and virus isolation in naturally infected shelter dogs.PloS one · 2023Article
- Canine Distemper Virus in Endangered Species: Species Jump, Clinical Variations, and Vaccination.Pathogens (Basel, Switzerland) · 2022Review
- Multiple Receptors Involved in Invasion and Neuropathogenicity of Canine Distemper Virus: A Review.Viruses · 2022Review
- Apoptotic investigation of brain tissue cells in dogs naturally infected by canine distemper virus.Virology journal · 2021Article
- Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.Autophagy · 2020Article
- Article
- Review
- Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy.Veterinary microbiology · 2020Article
- Measles Encephalitis: Towards New Therapeutics.Viruses · 2019Review
- Review
- Review
- Tropism and molecular pathogenesis of canine distemper virus.Virology journal · 2019Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine distemper virus (CDV) exhibits lymphotropic, epitheliotropic, and neurotropic nature, and causes a severe systemic infection in susceptible animals. Initially, signaling lymphocyte activation molecule (SLAM) expressed on immune cells has been identified as a crucial cellular receptor for CDV. Currently, nectin-4 expressed in epithelia has been shown to be another receptor for CDV. Our previous study demonstrated that neurons express nectin-4 and are infected with CDV. In this study, we investigated the distribution pattern of nectin-4 in various cell types in the canine central nervous system and showed its relation to CDV infection to further clarify the pathology of disease. Histopathological, immunohistochemical and immunofluorescent analyses were done using formalin-fixed paraffin-embedded tissues of CDV-infected dogs. Dual staining of nectin-4 and CDV antigen or nectin-4 and brain cell markers was performed. Nectin-4 was detected in ependymal cells, epithelia of choroid plexus, meningeal cells, neurons, granular cells, and Purkinje's cells. CDV antigens were detected in these nectin-4-positive cells, further suggesting contribution of nectin-4 for the CDV neurovirulence. On the other hand, astrocytes did not express nectin-4, although they were frequently infected with CDV. Since astrocytes are negative for SLAM expression, they must express an unidentified CDV receptor, which also contributes to CDV neurovirulence.
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