Evidence map›Paper›PMID 28336790›Full record

ReviewCirculation2017

Prioritizing Functional Capacity as a Principal End Point for Therapies Oriented to Older Adults With Cardiovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association.

Daniel E Forman, Ross Arena, Rebecca Boxer, Mary A Dolansky, Janice J Eng, Jerome L Fleg, Mark Haykowsky, Arshad Jahangir, Leonard A Kaminsky, Dalane W Kitzman and 5 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 159 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05618574 phase2completednot on this mapstarted 2023, after this paper: background citation

Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2023 to 2025Enrolled17ConditionsLong COVID, Cardiorespiratory FitnessArms140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK), 210 ml of nitrate-depleted placebo
NCT06842459 narecruitingnot on this mapstarted 2025, after this paper: background citation

Prevention of Functional Decline by Multimodal Intervention in Older Patients With Diabetes

TypeinterventionalSponsorUniversity of CagliariRan2025 to 2026Enrolled180ConditionsDiabetes, Older PeopleArmsGeriatric Assessment
3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  6. Guideline
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  11. Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020
    Guideline
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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Daniel E Forman
Ross Arena
Rebecca Boxer
Mary A Dolansky
Janice J Eng
Jerome L Fleg
Mark Haykowsky
Arshad Jahangir
Leonard A Kaminsky
Dalane W Kitzman
Eldrin F Lewis
Jonathan Myers
Gordon R Reeves
Win-Kuang Shen
American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council

Funding

Senior Research Career ScientistIK6RX002477 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI MYERS, JONATHAN N. · 2017 to 2025
–
RRD VA IK6 RX002477
6 · The paper itself

Abstract

Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has long been applied by cardiologists as a measure of function that depended primarily on cardiac physiology, multiple other factors also contribute, usually with increasing bearing as age advances. Comorbidity, inflammation, mitochondrial metabolism, cognition, balance, and sleep are among the constellation of factors that bear on cardiorespiratory function and that become intricately entwined with cardiovascular health in old age. This statement reviews the essential physiology underlying functional capacity on systemic, organ, and cellular levels, as well as critical clinical skills to measure multiple realms of function (eg, aerobic, strength, balance, and even cognition) that are particularly relevant for older patients. Clinical therapeutic perspectives and patient perspectives are enumerated to clarify challenges and opportunities across the caregiving spectrum, including patients who are hospitalized, those managed in routine office settings, and those in skilled nursing facilities. Overall, this scientific statement provides practical recommendations and vital conceptual insights.

Indexed as

American Heart AssociationCardiovascular DiseasesCardiovascular Physiological PhenomenaHumansRisk FactorsUnited StatesagedAHA Scientific Statementscardiopulmonary exercise testcardiorespiratory fitnessexercise tolerancefrail older adultsphysical activitysarcopenia

Identifiers

PMID28336790
PMCPMC7252210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.