ArticleScience (New York, N.Y.)2017
Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Land use and land cover change and its impacts on dengue dynamics in China: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Disruption of spatiotemporal clustering in dengue cases by wMel Wolbachia in Yogyakarta, Indonesia.Scientific reports · 2022Trial
- Dengue virus infection.Nature reviews. Disease primers · 2026Review
- Early warning of serotype replacement, spatial risk redistribution, and shifting clinical phenotypes: Insights from the 2023-2025 dengue outbreak in Meta, Colombia.PLoS neglected tropical diseases · 2026Observational
- The spatial structure of dengue transmission in Kamphaeng Phet Thailand.PLoS neglected tropical diseases · 2026Article
- Global source-sink dynamics of dengue viruses and epidemic establishment in areas on the fringe of endemic transmission.National science review · 2026Article
- Sociodemographic and Structural Risk Factors for Dengue in a Rapidly Developing Indonesian District.International journal of environmental research and public health · 2026Article
- Spatiotemporal dynamics of dengue: a town level study in Guangdong, China.BMC infectious diseases · 2026Article
- Projections of dengue epidemics attributable to climate change in Peru.BMJ global health · 2026Article
- Analyzing the influence of environment, demographic and socio-economic factors on Aedes albopictus (Diptera: Culicidae) mosquito density at the micro-level using XGBoost and SHAP.Parasites & vectors · 2026Article
- Phylogenetic insights into the transmission dynamics of arthropod-borne viruses.Nature reviews. Genetics · 2026Review
- Monitoring Dengue Virus inViruses · 2025Article
- Genomic and spatial heterogeneity of Brucella melitensis underscores latent brucellosis risks in non-endemic zones in Southwest China.Communications biology · 2025Article
- Multi-model approach to understand and predict past and future dengue epidemic dynamics.Royal Society open science · 2025Article
- Shifting Dynamics of Dengue Virus Serotype 2 and Emergence of Cosmopolitan Genotype, Costa Rica, 2024.Emerging infectious diseases · 2025Article
- Modeling Intraday Aedes-human exposure dynamics enhances dengue risk prediction.Scientific reports · 2025Article
- The disturbance of ABC transporters in patients with dengue fever: integration of metabolomics and transcriptomics.Frontiers in cellular and infection microbiology · 2025Article
- Review
- "Dengue fever is not just urban or rural: Reframing its spatial categorization."Social science & medicine (1982) · 2024Article
- Dengue virus genomic surveillance in the applying Wolbachia to eliminate dengue trial reveals genotypic efficacy and disruption of focal transmission.Scientific reports · 2024Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
A fundamental mystery for dengue and other infectious pathogens is how observed patterns of cases relate to actual chains of individual transmission events. These pathways are intimately tied to the mechanisms by which strains interact and compete across spatial scales. Phylogeographic methods have been used to characterize pathogen dispersal at global and regional scales but have yielded few insights into the local spatiotemporal structure of endemic transmission. Using geolocated genotype (800 cases) and serotype (17,291 cases) data, we show that in Bangkok, Thailand, 60% of dengue cases living <200 meters apart come from the same transmission chain, as opposed to 3% of cases separated by 1 to 5 kilometers. At distances <200 meters from a case (encompassing an average of 1300 people in Bangkok), the effective number of chains is 1.7. This number rises by a factor of 7 for each 10-fold increase in the population of the "enclosed" region. This trend is observed regardless of whether population density or area increases, though increases in density over 7000 people per square kilometer do not lead to additional chains. Within Thailand these chains quickly mix, and by the next dengue season viral lineages are no longer highly spatially structured within the country. In contrast, viral flow to neighboring countries is limited. These findings are consistent with local, density-dependent transmission and implicate densely populated communities as key sources of viral diversity, with home location the focal point of transmission. These findings have important implications for targeted vector control and active surveillance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.