ArticleArteriosclerosis, thrombosis, and vascular biology2017
Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima-Media Thickness in HIV-Infected Young Women in the Women's Interagency HIV Study.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Higher cardiovascular disease risks in people living with HIV: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Oxidized low-density lipoprotein associates with cardiovascular disease by a vicious cycle of atherosclerosis and inflammation: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- The impact of lipoprotein(a) determination in cardiovascular risk stratification among people living with HIV.Frontiers in cardiovascular medicine · 2026Article
- People living with HIV on modern antiretrovirals do not display a pro-atherogenic lipid profile and have similar body composition compared to healthy controls.HIV medicine · 2026Article
- PVAT adipocyte: energizing, modulating, and structuring vascular function during normotensive and hypertensive states.American journal of physiology. Heart and circulatory physiology · 2025Review
- Lipoprotein(a) Is Elevated and Inversely Related to Coronary Endothelial Function in People With HIV.Journal of the American Heart Association · 2024Article
- Racial and ethnic influences on carotid atherosclerosis: Epidemiology and risk factors.SAGE open medicine · 2024Review
- Elevated Lipoprotein(a) in Perinatally HIV-Infected Children Compared With Healthy Ethnicity-Matched Controls.Open forum infectious diseases · 2019Article
- Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families.Journal of lipid research · 2019Article
- Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study.Journal of lipid research · 2018Article
- Association of Lipoprotein(a) with peri-coronary inflammation in persons with and without HIV infection.Journal of clinical lipidologyArticle
- Variation in lipoprotein(a) response to potent lipid lowering: The role of apolipoprotein (a) isoform size.Journal of clinical lipidologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 1 country.
Byambaa EnkhmaaFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Erdembileg AnuuradFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Wei ZhangFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Chin-Shang LiFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Robert KaplanFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Jason LazarFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Dan MerensteinFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Roksana KarimFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Brad AouizeratFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Mardge CohenFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Kenneth ButlerFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Savita PahwaFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Igho OfotokunFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Adaora A AdimoraFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Elizabeth GolubFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.).
Lars BerglundFrom the Departments of Internal Medicine (B.E., E.A., W.Z., L.B.) and Public Health Sciences (C.-S.L.), University of California, Davis; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (R. Kaplan); Department of Cardiovascular Disease, SUNY Downstate Medical Center, Brooklyn, NY (J.L.); Department of Family Medicine, Georgetown University Medical Center, Washington, DC (D.M.); Department Preventive Medicine, University of Southern California, Los Angeles (R. Karim); Department of Oral and Maxillofacial Surgery, New York University (B.A.); Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL (M.C.); Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson (K.B.); Miami Center for AIDS Research, University of Miami, FL (S.P.); Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA (I.O.); Division of Infectious Diseases, University of North Carolina, Chapel Hill (A.A.A.); and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.G.). lberglund@ucdavis.edu.
SUNY Downstate Health Sciences University · USUniversity of Miami · USJackson Memorial Hospital · USJohn H. Stroger, Jr. Hospital of Cook County · USJohns Hopkins University · USUniversity of Southern California · USGeorgetown University Medical Center · USUniversity of Mississippi Medical Center · US
Funding
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MVirology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9MWomen's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7MWOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6MWomen's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5MWOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0MWomen's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0MUC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3MWOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0MWIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MEmory WIHS CRS - Longitudinal CohortU01AI103408 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WINGOOD, GINA MARIA · 2013 to 2018
$14.1MNCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001860NHLBI NIH HHS R01 HL062705NHLBI NIH HHS R01 HL065938NHLBI NIH HHS R01 HL126543NIAID NIH HHS P30 AI050410NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NICHD NIH HHS K12 HD051958NICHD NIH HHS U01 HD032632
Abstract
objectiveIn the general population, lipoprotein(a) [Lp(a)] has been established as an independent causal risk factor for cardiovascular disease. Lp(a) levels are to a major extent regulated by a size polymorphism in the apolipoprotein(a) [apo(a)] gene. The roles of Lp(a)/apo(a) in human immunodeficiency virus (HIV)-related elevated cardiovascular disease risk remain unclear. APPROACH AND
resultsThe associations between total plasma Lp(a) level, allele-specific apo(a) level, an Lp(a) level carried by individual apo(a) alleles, and common carotid artery intima-media thickness were assessed in 150 HIV-infected and 100 HIV-uninfected women in the WIHS (Women's Interagency HIV Study). Linear regression analyses with and without adjustments were used. The cohort was young (mean age, ≈31 years), with the majority being Blacks (≈70%). The prevalence of a small size apo(a) (≤22 Kringle repeats) or a high Lp(a) level (≥30 mg/dL) was similar by HIV status. Total plasma Lp(a) level (
conclusionsLp(a) and allele-specific apo(a) levels predict carotid artery intima-media thickness in HIV-infected young women. Further research is needed to identify underlying mechanisms of an increased Lp(a) atherogenicity in HIV infection.
Indexed as
AllelesCarotid Intima-Media ThicknessAdultApoprotein(a)BiomarkersCarotid Artery, CommonCarotid Artery DiseasesCase-Control StudiesFemaleHIV InfectionsHumansLinear ModelsPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsApoprotein(a)Biomarkersantiretroviral therapyapo(a) size, HIV treatmentapolipoprotein(a)cardiovascular riskcarotid artery intima–media thicknesslipoprotein(a)
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