Evidence map›Paper›PMID 28336549›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

EAVK segment "c" sequence confers Ca

Peter R Strege, Simon J Gibbons, Amelia Mazzone, Cheryl E Bernard, Arthur Beyder, Gianrico Farrugia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Differential Regulation of CaInternational journal of molecular sciences · 2021
    Article
  5. Allosteric modulation of alternatively spliced CaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Direct repression of anoctamin 1 (FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Peter R StregeEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Simon J GibbonsEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.ORCID http://orcid.org/0000-0001-5311-5993
Amelia MazzoneEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Cheryl E BernardEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Arthur BeyderEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota.
Gianrico FarrugiaEnteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota farrugia.gianrico@mayo.edu.
Mayo Clinic · US

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2M
CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
Mechanisms of mechanotransduction in the enterochromaffin cellsK08DK106456 · NIDDK · MAYO CLINIC ROCHESTER · PI BEYDER, ARTHUR · 2015 to 2019
$813k
NIDDK NIH HHS K08 DK106456NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK057061
6 · The paper itself

Abstract

Anoctamin1 (Ano1 and TMEM16A) is a calcium-activated chloride channel specifically expressed in the interstitial cells of Cajal (ICC) of the gastrointestinal tract muscularis propria. Ano1 is necessary for normal electrical slow waves and ICC proliferation. The full-length human Ano1 sequence includes an additional exon, exon "0," at the NH

Indexed as

Calcium SignalingAlternative SplicingAnoctamin-1CalciumChloride ChannelsExonsGastric MucosaHEK293 CellsHumansInterstitial Cells of CajalKineticsMembrane PotentialsNeoplasm ProteinsProtein DomainsProtein IsoformsStomachANO1 protein, humanAnoctamin-1CalciumChloride ChannelsNeoplasm ProteinsProtein Isoformselectrophysiologyion channelsTMEM16A

Identifiers

PMID28336549
PMCPMC5495914
OpenAlexW2599810854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.