Evidence map›Paper›PMID 28336424›Full record

ReviewProgress in retinal and eye research2017

The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.

Sayantan Datta, Marisol Cano, Katayoon Ebrahimi, Lei Wang, James T Handa

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in retinal and eye research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 495 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
495citing papers in PubMed, 8 pooled it
47.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

495 citing papers in PubMed, 8 syntheses or guidelines pooled it, 765 citations in OpenAlex.

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435 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sayantan DattaWilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD USA.
Marisol CanoWilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD USA.
Katayoon EbrahimiWilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD USA.
Lei WangWilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD USA.
James T HandaWilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD USA. Electronic address: jthanda@jhmi.edu.
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
AGE-induced Phenotype of the Retinal Pigment EpitheliumR01EY014005 · NEI · JOHNS HOPKINS UNIVERSITY · PI HANDA, JAMES T · 2001 to 2015
$6.4M
Nrf2 signaling and oxidative stress in Age-related macular degenerationR01EY019904 · NEI · JOHNS HOPKINS UNIVERSITY · PI HANDA, JAMES T · 2010 to 2016
$4.1M
Oxidative stress and innate immunity impair the visual cycleR01EY027691 · NEI · JOHNS HOPKINS UNIVERSITY · PI HANDA, JAMES T · 2017 to 2021
$2.7M
NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY014005NEI NIH HHS R01 EY019904NEI NIH HHS R01 EY027691
6 · The paper itself

Abstract

The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that interacts with photoreceptors on its apical side and with Bruch's membrane and the choriocapillaris on its basal side. Due to vital functions that keep photoreceptors healthy, the RPE is essential for maintaining vision. With aging and the accumulated effects of environmental stresses, the RPE can become dysfunctional and die. This degeneration plays a central role in age-related macular degeneration (AMD) pathobiology, the leading cause of blindness among the elderly in western societies. Oxidative stress and inflammation have both physiological and potentially pathological roles in RPE degeneration. Given the central role of the RPE, this review will focus on the impact of oxidative stress and inflammation on the RPE with AMD pathobiology. Physiological sources of oxidative stress as well as unique sources from photo-oxidative stress, the phagocytosis of photoreceptor outer segments, and modifiable factors such as cigarette smoking and high fat diet ingestion that can convert oxidative stress into a pathological role, and the negative impact of impairing the cytoprotective roles of mitochondrial dynamics and the Nrf2 signaling system on RPE health in AMD will be discussed. Likewise, the response by the innate immune system to an inciting trigger, and the potential role of local RPE production of inflammation, as well as a potential role for damage by inflammation with chronicity if the inciting trigger is not neutralized, will be debated.

Indexed as

HumansImmunity, InnateMacular DegenerationMitochondriaOxidative StressPhagocytosisRetinal Pigment EpitheliumRisk FactorsAge-related macular degenerationComplementInflammationMitochondrial dynamicsNrf2Oxidative stressRetinal pigment epithelium

Identifiers

PMID28336424
PMCPMC5600827
OpenAlexW2602573314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.