Evidence map›Paper›PMID 28336049›Full record

ReviewLancet (London, England)2017

Hypothyroidism.

Layal Chaker, Antonio C Bianco, Jacqueline Jonklaas, Robin P Peeters

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 532 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
532citing papers in PubMed, 11 pooled it
41.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

532 citing papers in PubMed, 11 syntheses or guidelines pooled it, 1,089 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

472 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Layal ChakerAcademic Centre for Thyroid Disease, Erasmus University Medical Centre, Rotterdam, Netherlands.
Antonio C BiancoDivision of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL, USA.
Jacqueline JonklaasDivision of Endocrinology, Georgetown University, Washington, DC, USA.
Robin P PeetersAcademic Centre for Thyroid Disease, Erasmus University Medical Centre, Rotterdam, Netherlands. Electronic address: r.peeters@erasmusmc.nl.
Erasmus University Rotterdam · NLGeorgetown University · USRush University Medical Center · US

Funding

Thyroid-adrenergic synergism and adaptive thermogenesisR01DK065055 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIANCO, ANTONIO C · 2005 to 2021
$4.4M
NIDDK NIH HHS R01 DK065055
6 · The paper itself

Abstract

Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors. The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. In this Seminar, we discuss the epidemiology, causes, and symptoms of hypothyroidism; summarise evidence on diagnosis, long-term risk, treatment, and management; and highlight future directions for research.

Indexed as

Disease ManagementHormone Replacement TherapyHypothyroidismThyroxineThyroxine

Identifiers

PMID28336049
PMCPMC6619426
OpenAlexW4211084027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.