Evidence map›Paper›PMID 28335999›Full record

ArticleUltrasound in medicine & biology2017

Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery.

Prasanna Hariharan, Marjan Nabili, Allan Guan, Vesna Zderic, Matthew Myers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Therapeutic Ultrasound for Topical Corneal Delivery of Macromolecules.Translational vision science & technology · 2022
    Article
  6. Article
  7. Novel insights into gene therapy in the cornea.Experimental eye research · 2021
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Prasanna HariharanCenter for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA.
Marjan NabiliCenter for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA.
Allan GuanDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Vesna ZdericDepartment of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Matthew MyersCenter for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA. Electronic address: matthew.myers@fda.hhs.gov.
Center for Devices and Radiological Health · USGeorge Washington University · US

Funding

Ultrasound-Enhanced Ocular Drug DeliveryR21EY018737 · NEI · GEORGE WASHINGTON UNIVERSITY · PI ZDERIC, VESNA · 2009 to 2010
$371k
NEI NIH HHS R21 EY018737
6 · The paper itself

Abstract

Ultrasound-enhanced drug delivery through the cornea has considerable therapeutic potential. However, our understanding of how ultrasound enhances drug transport is poor, as is our ability to predict the increased level of transport for given ultrasound parameters. Described here is a computational model for quantifying changes in corneal porosity during ultrasound exposure. The model is calibrated through experiments involving sodium fluorescein transport through rabbit cornea. Validation was performed using nylon filters, for which the properties are known. It was found that exposure to 800-kHz ultrasound at an intensity 2 W/cm

Indexed as

Models, BiologicalAdministration, OphthalmicComputer SimulationCorneaDiffusionElectroporationHigh-Energy Shock WavesHumansPharmaceutical PreparationsPorosityRadiation DosageSonicationPharmaceutical PreparationsDrug deliveryOcularPorous medium modelUltrasound

Identifiers

PMID28335999
PMCPMC5768443
OpenAlexW2600992741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.