ArticleJournal of the American Academy of Child and Adolescent Psychiatry2017
Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.Psychological bulletin · 2020Pooled it
- Meta-analysis: Exposure to Early Life Stress and Risk for Depression in Childhood and Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Pooled it
- Impaired hippocampus-dependent associative learning as a mechanism underlying PTSD: A meta-analysis.Neuroscience and biobehavioral reviews · 2019Pooled it
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Early Exposure to Deprivation or Threat Moderates Expected Associations Between Neural Structure and Age in Adolescent Girls.Child maltreatment · 2025Article
- Prevalence, determinants, and complications of adolescent pregnancy: an umbrella review of systematic reviews and meta-analyses.AJOG global reports · 2025Review
- High transmission risk in HIV-1 molecular transmission network among MSM is related to unsafe sexual behavior and adverse childhood experiences: a case-control study.Frontiers in public health · 2025Article
- Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025Review
- Impact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis.Psychiatry research · 2024Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Diffusion tensor imaging of white-matter structural features of maltreating mothers and their associations with intergenerational chain of childhood abuse.Scientific reports · 2024Article
- Trauma and the default mode network: review and exploratory study.Frontiers in behavioral neuroscience · 2024Article
- Developmental Correlates of Accelerated Molar Eruption in Early Childhood.Biological psychiatry global open science · 2023Article
- Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis.BMC psychology · 2023Article
- Distinct Associations of Deprivation and Threat With Alterations in Brain Structure in Early Childhood.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Long-term effects of childhood trauma subtypes on adult brain function.Brain and behavior · 2023Article
- Traumatic stress load and stressor reactivity score associated with accelerated gray matter maturation in youths indexed by normative models.Molecular psychiatry · 2023Article
- Anxiety onset in adolescents: a machine-learning prediction.Molecular psychiatry · 2023Article
- Longitudinal changes in brain structure and their relationship with subclinical psychiatric symptoms in parents who lost their only child in China.European journal of psychotraumatology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveChild abuse exerts a deleterious impact on a broad array of mental health outcomes. However, the neurobiological mechanisms that mediate this association remain poorly characterized. Here, we use a longitudinal design to prospectively identify neural mediators of the association between child abuse and psychiatric disorders in a community sample of adolescents.
methodStructural magnetic resonance imaging (MRI) data and assessments of mental health were acquired for 51 adolescents (aged 13-20; M=16.96; SD=1.51), 19 of whom were exposed to physical or sexual abuse. Participants were assessed for abuse exposure (time 1), participated in MRI scanning and a diagnostic structured interview (time 2), and 2 years later were followed-up to assess psychopathology (time 3). We examined associations between child abuse and neural structure, and identified whether abuse-related differences in neural structure prospectively predicted psychiatric symptoms.
resultsAbuse was associated with reduced cortical thickness in medial and lateral prefrontal and temporal lobe regions. Thickness of the left and right parahippocampal gyrus predicted antisocial behavior symptoms, and thickness of the middle temporal gyrus predicted symptoms of generalized anxiety disorder. Thickness of the left parahippocampal gyrus mediated the longitudinal association of abuse with antisocial behavior.
conclusionChild abuse is associated with widespread disruptions in cortical structure, and these disruptions are selectively associated with increased vulnerability to internalizing and externalizing psychopathology. Identifying predictive biomarkers of vulnerability following childhood maltreatment may uncover neurodevelopmental mechanisms linking environmental experience with the onset of psychopathology.
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