Evidence map›Paper›PMID 28335824›Full record

ArticleJournal of orthopaedic surgery and research2017

The biomechanical and histological effects of posterior cruciate ligament rupture on the medial tibial plateau.

Zhenhan Deng, Yusheng Li, Zhangyuan Lin, Yong Zhu, Ruibo Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhenhan DengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Yusheng LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Zhangyuan LinDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Yong ZhuDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Ruibo ZhaoDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. drruibozhao@163.com.
Xiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to investigate the biomechanical and histological effects of the posterior cruciate ligament (PCL) on the medial tibial plateau.

methodsA total of 12 cadaveric human knee specimens were collected and grouped as follows: the PCL intact group (n = 12), the anterolateral bundle rupture group (n = 6), the postmedial bundle rupture group (n = 6), and the PCL rupture group (n = 12). The strain on the anterior, middle, and posterior parts of the medial tibial plateau with an axial loading force at different flexion angles was measured and analyzed, respectively. Forty-eight rabbits were chosen for animal study: surgery was performed on the one side of each rabbit randomly (experimental group), while the other side was taken as control (control group). Every 12 rabbits were culled at each of the four selected time points to collect the medial tibial plateau for morphological and histological observation.

resultsThe PCL rupture, either partial or complete, may generate an abnormal load on all the parts of the medial tibial plateau with axial loading at all positions. Noticeable time-dependent degenerative histological changes of the medial tibial plateau were observed in the rabbit models of PCL rupture. Compared with the control group, all the PCL rupture groups exhibited a higher expression of the matrix metalloproteinase-7 (MMP-7) and the tissue inhibitors of metalloproteinase-1 (TIMP-1) at all the time points.

conclusionsEither partial or complete PCL rupture may generate an abnormal load on all the parts of the medial tibial plateau with axial loading at all the positions and may cause cartilage degeneration on the medial tibial plateau.

Indexed as

AdultAnimalsBiomechanical PhenomenaCadaverHumansKnee JointMaleMatrix Metalloproteinase 13Posterior Cruciate LigamentRabbitsRuptureStress, MechanicalTibiaTissue Inhibitor of Metalloproteinase-1Weight-BearingMatrix Metalloproteinase 13Tissue Inhibitor of Metalloproteinase-1Mankin scoreMedial tibial plateauMMP-7PCL ruptureTIMP-1

Identifiers

PMID28335824
PMCPMC5364568
OpenAlexW2601356300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.