Evidence map›Paper›PMID 28335810›Full record

Trial reportAlzheimer's research & therapy2017

Structured relearning of activities of daily living in dementia: the randomized controlled REDALI-DEM trial on errorless learning.

Sebastian Voigt-Radloff, Maartje M E de Werd, Rainer Leonhart, Danielle H E Boelen, Marcel G M Olde Rikkert, Klaus Fliessbach, Stefan Klöppel, Bernhard Heimbach, Andreas Fellgiebel, Richard Dodel and 4 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Cognitive rehabilitation for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Cognitive training for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Prescribing Assistive Technology for Cognition to Support Aging in Place: OTs' Perspective.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Sebastian Voigt-RadloffCenter for Geriatric Medicine and Gerontology, University Medical Center Freiburg, Freiburg, Germany.
Maartje M E de WerdDepartment of Medical Psychology & Radboudumc Alzheimer Center, Radboud University Medical Center, P.O. Box 9101 (internal post 925), 6500 HB, Nijmegen, The Netherlands.
Rainer LeonhartDepartment of Social Psychology & Methodology, University of Freiburg, Psychological Institute, Freiburg, Germany.
Danielle H E BoelenDepartment of Medical Psychology & Radboudumc Alzheimer Center, Radboud University Medical Center, P.O. Box 9101 (internal post 925), 6500 HB, Nijmegen, The Netherlands.
Marcel G M Olde RikkertDepartment of Geriatric Medicine & Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.
Klaus FliessbachDepartment of Psychiatry and Psychotherapy, University Medical Center Bonn, Bonn, Germany.
Stefan KlöppelCenter for Geriatric Medicine and Gerontology, University Medical Center Freiburg, Freiburg, Germany.
Bernhard HeimbachCenter for Geriatric Medicine and Gerontology, University Medical Center Freiburg, Freiburg, Germany.
Andreas FellgiebelDepartment of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
Richard DodelDepartment of Neurology, Philipps University Marburg, Marburg, Germany.
Gerhard W EschweilerGeriatric Center, University Hospital Tübingen, Tübingen, Germany.
Lucrezia HausnerDepartment of Gerontopsychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Roy P C KesselsDepartment of Medical Psychology & Radboudumc Alzheimer Center, Radboud University Medical Center, P.O. Box 9101 (internal post 925), 6500 HB, Nijmegen, The Netherlands. Roy.Kessels@radboudumc.nl.ORCID http://orcid.org/0000-0001-9500-9793
Michael HüllCenter for Geriatric Medicine and Gerontology, University Medical Center Freiburg, Freiburg, Germany.
Radboud University Nijmegen · NLUniversity Medical Center Freiburg · DEGerman Center for Neurodegenerative Diseases · DEHeidelberg University · DEJohannes Gutenberg University Mainz · DEPhilipps University of Marburg · DEUniversity Children's Hospital Tübingen · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundErrorless learning (EL) is a method for optimizing learning, which uses feed-forward instructions in order to prevent people from making mistakes during the learning process. The majority of previous studies on EL taught patients with dementia artificial tasks of little or no relevance for their daily lives. Furthermore, only a few controlled studies on EL have so far been performed and just a handful of studies have examined the long-term effects of EL. Tasks were not always trained in the patients' natural or home environment, limiting the external validity of these studies. This multicenter parallel randomized controlled trial examines the effects of EL compared with trial and error learning (TEL) on the performance of activities of daily living in persons with Alzheimer's or mixed-type dementia living at home.

methodsPatients received nine 1-hour task training sessions over eight weeks using EL or TEL. Task performance was measured using video observations at week 16. Secondary outcome measures were task performance measured at week 26, satisfaction with treatment, need for assistance, challenging behavior, adverse events, resource utilization and treatment costs.

resultsA total of 161 participants were randomized, of whom 71 completed the EL and 74 the TEL arm at week 11. Sixty-nine EL patients and 71 TEL patients were assessed at the 16-week follow-up (the primary measurement endpoint). Intention-to-treat analysis showed a significantly improved task performance in both groups. No significant differences between the treatment groups were found for primary or secondary outcomes.

conclusionsStructured relearning improved the performance of activities of daily living. Improvements were maintained for 6 months. EL had no additional effect over TEL.

trial registrationGerman Register of Clinical Trials DRKS00003117 . Registered 31 May 2011.

Indexed as

Activities of Daily LivingPsychomotor PerformanceAgedBiofeedback, PsychologyDementiaFemaleHumansLearningMaleNetherlandsNeurological RehabilitationSingle-Blind MethodTreatment OutcomeActivities of daily livingAlzheimer’s dementiaCognitive rehabilitationDementiaErrorless learningRandomized controlled trial

Identifiers

PMID28335810
PMCPMC5364615
OpenAlexW2599120715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.