Trial reportRadiation oncology (London, England)2017
Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: a multi-institutional study.
Trial report in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Target Contour Consistency During Magnetic Resonance-Guided Online Adaptive Stereotactic Body Radiation Therapy.Advances in radiation oncology · 2025Article
- Computer-Aided Decision Support and 3D Models in Pancreatic Cancer Surgery: A Pilot Study.Journal of clinical medicine · 2025Article
- Impact of motion management strategies on abdominal organ at risk delineation for magnetic resonance-guided radiotherapy.Physics and imaging in radiation oncology · 2024Article
- A comparison of target volumes drawn on arterial and venous phase scans during radiation therapy planning for patients with pancreatic cancer: the PANCRINJ study.Radiation oncology (London, England) · 2024Article
- Computer-Aided Detection for Pancreatic Cancer Diagnosis: Radiological Challenges and Future Directions.Journal of clinical medicine · 2023Review
- Evaluating differences in respiratory motion estimates during radiotherapy: a single planning 4DMRI versus daily 4DMRI.Radiation oncology (London, England) · 2021Article
- Effects of interobserver and interdisciplinary segmentation variabilities on CT-based radiomics for pancreatic cancer.Scientific reports · 2021Article
- A novel amplitude binning strategy to handle irregular breathing during 4DMRI acquisition: improved imaging for radiotherapy purposes.Radiation oncology (London, England) · 2019Article
- Differences in gross tumor volumes for pancreatic cancer: a comparison of ungated positron emission tomography and contrast-enhanced four-dimensional computed tomography.Japanese journal of radiology · 2019Article
- Article
- Dosimetric effects of anatomical changes during fractionated photon radiation therapy in pancreatic cancer patients.Journal of applied clinical medical physics · 2017Article
- Quality assurance of the PREOPANC trial (2012-003181-40) for preoperative radiochemotherapy in pancreatic cancer : The dummy run.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Article
- Inter-Observer Variability in MR-Based Target Volume Delineation of Uveal Melanoma.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe delineation of pancreatic tumors on CT is challenging. In this study, we quantified the interobserver variation for pancreatic tumor delineation on 3DCT as well as on 4DCT.
methodsEight observers (radiation oncologists) from six institutions delineated pancreatic tumors of four patients with (borderline) resectable pancreatic cancer. The study consisted of two stages. In the 3DCT-stage, the gross tumor volume (GTV) was delineated on a contrast-enhanced scan. In the 4DCT-stage, the internal GTV (iGTV) was delineated, accounting for the respiratory motion. We calculated the volumes of the (i)GTV, the overlap of the delineated volumes (expressed as generalized conformity index: CI
resultsThe ratios of the largest to the smallest delineated GTV and iGTV within the same patient were 6.8 and 16.5, respectively. As the iGTV incorporates the GTV during all respiratory phases, the mean volumes of the iGTV (40.07 cm
conclusionsA considerable interobserver variation in delineation of pancreatic tumors was observed. This variation was larger for 4D than for 3D delineation. The largest local observer variation was found around biliary stents and suspicious pathological enlarged lymph nodes.
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