ArticleBMC evolutionary biology2017
Transcriptomic insights into the genetic basis of mammalian limb diversity.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Body mass evolution as a driver of morphological and ecological diversity in terrestrial mammals.BMC ecology and evolution · 2025Article
- Different Species of Bats: Genomics, Transcriptome, and Immune Repertoire.Current issues in molecular biology · 2025Review
- Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation.Nature communications · 2025Article
- Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals.Innovation (Cambridge (Mass.)) · 2023Article
- Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development.BMC biology · 2023Article
- Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity.eLife · 2023Article
- Timing of organogenesis underscores the evolution of neonatal life histories and powered flight in bats.Proceedings. Biological sciences · 2023Article
- Non-model systems in mammalian forelimb evo-devo.Current opinion in genetics & development · 2021Review
- Diversification of the vertebrate limb: sequencing the events.Current opinion in genetics & development · 2021Review
- Cross-species comparisons andInterface focus · 2021Review
- Article
- Making a bat: The developmental basis of bat evolution.Genetics and molecular biology · 2021Article
- Developmental and Evolutionary Allometry of the Mammalian Limb Skeleton.Integrative and comparative biology · 2019Review
- Pigeon foot feathering reveals conserved limb identity networks.Developmental biology · 2019Article
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Authors and funding
11 authors.
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Abstract
backgroundFrom bat wings to whale flippers, limb diversification has been crucial to the evolutionary success of mammals. We performed the first transcriptome-wide study of limb development in multiple species to explore the hypothesis that mammalian limb diversification has proceeded through the differential expression of conserved shared genes, rather than by major changes to limb patterning. Specifically, we investigated the manner in which the expression of shared genes has evolved within and among mammalian species.
resultsWe assembled and compared transcriptomes of bat, mouse, opossum, and pig fore- and hind limbs at the ridge, bud, and paddle stages of development. Results suggest that gene expression patterns exhibit larger variation among species during later than earlier stages of limb development, while within species results are more mixed. Consistent with the former, results also suggest that genes expressed at later developmental stages tend to have a younger evolutionary age than genes expressed at earlier stages. A suite of key limb-patterning genes was identified as being differentially expressed among the homologous limbs of all species. However, only a small subset of shared genes is differentially expressed in the fore- and hind limbs of all examined species. Similarly, a small subset of shared genes is differentially expressed within the fore- and hind limb of a single species and among the forelimbs of different species.
conclusionsTaken together, results of this study do not support the existence of a phylotypic period of limb development ending at chondrogenesis, but do support the hypothesis that the hierarchical nature of development translates into increasing variation among species as development progresses.
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