Evidence map›Paper›PMID 28335679›Full record

ArticleRenal failure2017

Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro.

Xiangjun Zhou, Chen Bai, Xinbo Sun, Xiaoxin Gong, Yong Yang, Congbo Chen, Guang Shan, Qisheng Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
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  4. Nephroprotective activity of Eysenhardtia polystachya through antioxidant, HNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
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  7. Review
  8. Review
  9. Article
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  14. Review
  15. Therapeutic Implications of Ferroptosis in Renal Fibrosis.Frontiers in molecular biosciences · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiangjun Zhoua Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Chen Baib Department of General Surgery , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Xinbo Suna Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Xiaoxin Gonga Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Yong Yanga Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Congbo Chena Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Guang Shanc Department of Urology , Renmin Hospital of Wuhan University , Hubei , China.
Qisheng Yaoa Department of Urology , Taihe Hospital, Hubei University of Medicine , Hubei , China.
Taihe Hospital · CNHubei University of Medicine · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Puerarin (PR) is an isoflavonoid isolated from the root of the plant Pueraria lobata and has been widely used in traditional Chinese herbal medicine for the treatment of various diseases. Oxidative stress and epithelial cell apoptosis play important roles in the renal fibrotic process. The present study aimed to determine whether or not PR inhibits renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis. In vivo, unilateral ureteral obstruction (UUO) induced renal fibrosis, and epithelial cell apoptosis. A total of 24 mice were randomly assigned to four experimental groups: sham, UUO alone, UUO +50 mg/kg PR, and UUO +100 mg/kg PR. In vitro, 200 μM hydrogen peroxide (H

Indexed as

AnimalsApoptosisCaspase 3Drugs, Chinese HerbalEpithelial CellsExtracellular Signal-Regulated MAP KinasesFibrosisFlow CytometryHydrogen PeroxideIn Situ Nick-End LabelingIsoflavonesJNK Mitogen-Activated Protein KinasesKidneyKidney TubulesMaleMAP Kinase Signaling SystemCasp3 protein, mouseCaspase 3Drugs, Chinese HerbalExtracellular Signal-Regulated MAP KinasesHydrogen PeroxideIsoflavonesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesNADPH Oxidase 4NADPH OxidasesNox4 protein, mousep38 Mitogen-Activated Protein Kinasespuerarinepithelial cell apoptosisoxidative stressPuerarinrenal fibrosistubular injury

Identifiers

PMID28335679
PMCPMC6014507
OpenAlexW2604037323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.