Evidence map›Paper›PMID 28335624›Full record

Trial reportThe American journal of psychiatry2017

Effects of Patient Preferences on Outcomes in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) Study.

Boadie W Dunlop, Mary E Kelley, Vivianne Aponte-Rivera, Tanja Mletzko-Crowe, Becky Kinkead, James C Ritchie, Charles B Nemeroff, W Edward Craighead, Helen S Mayberg, PReDICT Team

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 6 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  10. Functional connectivity of salience and affective networks among remitted depressed patients predicts episode recurrence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  13. Rostral anterior cingulate network effective connectivity in depressed adolescents and associations with treatment response in a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Boadie W DunlopFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Mary E KelleyFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Vivianne Aponte-RiveraFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Tanja Mletzko-CroweFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Becky KinkeadFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
James C RitchieFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Charles B NemeroffFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
W Edward CraigheadFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Helen S MaybergFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
PReDICT TeamFrom the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta; the Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta; the Department of Psychiatry and Behavioral Sciences, Tulane University School of Medicine, New Orleans; the Department of Clinical Pathology, Emory University School of Medicine, Atlanta; the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami; the Department of Psychology, Emory University, Atlanta; and the Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta.
Emory University · USUniversity of Miami · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
Special Scientific Procedures: Statistical Modeling CoreP50MH077083 · NIMH · EMORY UNIVERSITY · PI MAYBERG, HELEN S · 2006 to 2010
$9.3M
Predictors of Treatment Response Relapse and Recurrence in Major DepressionR01MH080880 · NIMH · EMORY UNIVERSITY · PI CRAIGHEAD, W. EDWARD · 2008 to 2012
$6.6M
Neural Correlates of Loss Aversion in Major DepressionK23MH086690 · NIMH · EMORY UNIVERSITY · PI DUNLOP, BOADIE W · 2009 to 2011
$521k
NCRR NIH HHS M01 RR000039NCRR NIH HHS UL1 RR025008NIMH NIH HHS K23 MH086690NIMH NIH HHS P50 MH077083NIMH NIH HHS R01 MH080880
6 · The paper itself

Abstract

objectiveThe Predictors of Remission in Depression to Individual and Combined Treatments [PReDICT] study aimed to identify clinical and biological factors predictive of treatment outcomes in major depressive disorder among treatment-naive adults. The authors evaluated the efficacy of cognitive-behavioral therapy (CBT) and two antidepressant medications (escitalopram and duloxetine) in patients with major depression and examined the moderating effect of patients' treatment preferences on outcomes.

methodAdults aged 18-65 with treatment-naive major depression were randomly assigned with equal likelihood to 12 weeks of treatment with escitalopram (10-20 mg/day), duloxetine (30-60 mg/day), or CBT (16 50-minute sessions). Prior to randomization, patients indicated whether they preferred medication or CBT or had no preference. The primary outcome was change in the 17-item Hamilton Depression Rating Scale (HAM-D), administered by raters blinded to treatment.

resultsA total of 344 patients were randomly assigned, with a mean baseline HAM-D score of 19.8 (SD=3.8). The mean estimated overall decreases in HAM-D score did not significantly differ between treatments (CBT: 10.2, escitalopram: 11.1, duloxetine: 11.2). Last observation carried forward remission rates did not significantly differ between treatments (CBT: 41.9%, escitalopram: 46.7%, duloxetine: 54.7%). Patients matched to their preferred treatment were more likely to complete the trial but not more likely to achieve remission.

conclusionsTreatment guidelines that recommend either an evidence-based psychotherapy or antidepressant medication for nonpsychotic major depression can be extended to treatment-naive patients. Treatment preferences among patients without prior treatment exposure do not significantly moderate symptomatic outcomes.

Indexed as

Cognitive Behavioral TherapyOutcome Assessment, Health CarePatient PreferenceAdultAntidepressive AgentsCitalopramCombined Modality TherapyDuloxetine HydrochlorideFemaleHumansMajor Depressive DisorderMaleMiddle AgedPsychiatric Status Rating ScalesPsychometricsTreatment OutcomeAntidepressive AgentsCitalopramDuloxetine HydrochlorideAntidepressantsCognitive TherapyMood Disorders-UnipolarOutcome Studies

Identifiers

PMID28335624
PMCPMC6690210
OpenAlexW2601834048

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.