ArticleMolecules (Basel, Switzerland)2017
New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Progress in the Synthesis of Organoselenium Compounds: Conventional Routes Versus Green Approaches.Molecules (Basel, Switzerland) · 2026Review
- Organoselenium Compounds Derived from Natural Metabolites.Pharmaceuticals (Basel, Switzerland) · 2025Review
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- Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain.ACS medicinal chemistry letters · 2024Article
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- Synthesis of New ChiralMaterials (Basel, Switzerland) · 2024Article
- Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2.Mini reviews in medicinal chemistry · 2024Review
- The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties ofPharmaceuticals (Basel, Switzerland) · 2023Article
- SelectedMolecules (Basel, Switzerland) · 2023Article
- Attachment of Chiral Functional Groups to Modify the Activity of New GPx Mimetics.Materials (Basel, Switzerland) · 2022Article
- Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation.Molecules (Basel, Switzerland) · 2021Review
- Sweet Selenium: Synthesis and Properties of Selenium-Containing Sugars and Derivatives.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Phenylselanyl Group Incorporation for "Glutathione Peroxidase-Like" Activity Modulation.Molecules (Basel, Switzerland) · 2020Article
- In Vitro Anti-Prostate Cancer Activity of Two Ebselen Analogues.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Seleninic Acid Potassium Salts as Water-Soluble Biocatalysts with Enhanced Bioavailability.Materials (Basel, Switzerland) · 2020Article
- Bioselectivity Induced by Chirality of New Terpenyl Organoselenium Compounds.Materials (Basel, Switzerland) · 2019Article
- Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms.Antioxidants (Basel, Switzerland) · 2018Article
- Celebrating Two Centuries of Research in Selenium Chemistry: State of the Art and New Prospective.Molecules (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New chiral camphane-derived benzisoselenazol-3(2H)-ones and corresponding diselenides have been synthetized using a convenient one-pot procedure. Se-N bond was efficiently converted to an Se-Se bond, which could also be easily re-oxidized to the initial benzisoselenazolone moiety. The antioxidant activity of camphor derivatives was evaluated and compared to the reactivity of a series of N-amino acid benzisoselenazol-3(2H)-ones obtained by a modified procedure involving the improved synthesis and isolation of the diseleno bis(dibenzoic) acid. The most efficient peroxide scavengers, N-bornyl and N-leucine methyl ester benzisoselenazol-3(2H)-ones, were further evaluated as cytotoxic agents on four cancer cell lines (MCF-7, HEP G2, HL 6, and DU 145) and normal cell line PNT1A. The highest antiproliferative potential was evaluated for two compounds bearing a 3-methylbutyl carbon chain, N-leucine methyl ester and N-3-methylbutyl benzisoselenazol-3(2H)-ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.