Evidence map›Paper›PMID 28335474›Full record

ArticleViruses2017

Coccolithoviruses: A Review of Cross-Kingdom Genomic Thievery and Metabolic Thuggery.

Jozef I Nissimov, António Pagarete, Fangrui Ma, Sean Cody, David D Dunigan, Susan A Kimmance, Michael J Allen

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Jozef I NissimovPlymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth PL1 3DH, UK. jnissimov@marine.rutgers.edu.
António PagareteDepartment of Biology, University of Bergen, Bergen, 7803, Norway. antonio.pagarete@uib.no.
Fangrui MaNebraska Center for Virology, University of Nebraska, Lincoln, NE 68583, USA. fma2@unl.edu.
Sean CodyNebraska Center for Virology, University of Nebraska, Lincoln, NE 68583, USA. wfr1995@gmail.com.
David D DuniganNebraska Center for Virology, University of Nebraska, Lincoln, NE 68583, USA. ddunigan2@unl.edu.
Susan A KimmancePlymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth PL1 3DH, UK. sukim@pml.ac.uk.
Michael J AllenPlymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth PL1 3DH, UK. mija@pml.ac.uk.
University of Nebraska–Lincoln · USPlymouth Marine Laboratory · GBRutgers, The State University of New Jersey · USUniversity of Bergen · NO

Funding

Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
NIGMS NIH HHS P30 GM103509
6 · The paper itself

Abstract

Coccolithoviruses (Phycodnaviridae) infect and lyse the most ubiquitous and successful coccolithophorid in modern oceans, Emiliania huxleyi. So far, the genomes of 13 of these giant lytic viruses (i.e., Emiliania huxleyi viruses-EhVs) have been sequenced, assembled, and annotated. Here, we performed an in-depth comparison of their genomes to try and contextualize the ecological and evolutionary traits of these viruses. The genomes of these EhVs have from 444 to 548 coding sequences (CDSs). Presence/absence analysis of CDSs identified putative genes with particular ecological significance, namely sialidase, phosphate permease, and sphingolipid biosynthesis. The viruses clustered into distinct clades, based on their DNA polymerase gene as well as full genome comparisons. We discuss the use of such clustering and suggest that a gene-by-gene investigation approach may be more useful when the goal is to reveal differences related to functionally important genes. A multi domain "Best BLAST hit" analysis revealed that 84% of the EhV genes have closer similarities to the domain Eukarya. However, 16% of the EhV CDSs were very similar to bacterial genes, contributing to the idea that a significant portion of the gene flow in the planktonic world inter-crosses the domains of life.

Indexed as

EcosystemEvolution, MolecularGenes, BacterialGenetic VariationGene Transfer, HorizontalGenome SizeGenome, ViralHaptophytaPhycodnaviridaePhylogenySequence Analysis, DNASpecies Specificitycoccolithovirusdomains of lifeE. huxleyigenome comparisonhorizontal gene transfer

Identifiers

PMID28335474
PMCPMC5371807
OpenAlexW2598407581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.