Evidence map›Paper›PMID 28335428›Full record

ReviewMarine drugs2017

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management.

Melissa A Friedman, Mercedes Fernandez, Lorraine C Backer, Robert W Dickey, Jeffrey Bernstein, Kathleen Schrank, Steven Kibler, Wendy Stephan, Matthew O Gribble, Paul Bienfang and 13 more

Abstract readReview
In one paragraph

Review in Marine drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Poison Apple-like Fruit Ingestion: A Case Report and Review of Manchineel Fruit Toxicity.International journal of environmental research and public health · 2026
    Review
  3. Article
  4. Article
  5. Foodborne Disease Outbreaks Associated with Marine Toxins - Foodborne Disease Outbreak Surveillance System, United States, 2011-2023.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2026
    Article
  6. Review
  7. Article
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  10. Review
  11. Article
  12. Article
  13. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Melissa A FriedmanMount Sinai Medical Center, Miami Beach, FL 33140, USA. melissafried@yahoo.com.
Mercedes FernandezDepartment of Psychology and Neuroscience, Nova Southeastern University, Fort Lauderdale, FL 33314, USA. mf934@nova.edu.
Lorraine C BackerNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. lfb9@cdc.gov.
Robert W DickeyMarine Science Institute, University of Texas at Austin, Port Aransas, TX 78373, USA. robt.dickey@austin.utexas.edu.
Jeffrey BernsteinJackson Memorial Medical Center, Department of Medicine, University of Miami, Miami, FL 33136, USA. jbernstein@med.miami.edu.
Kathleen SchrankJackson Memorial Medical Center, Department of Medicine, University of Miami, Miami, FL 33136, USA. kschrank@med.miami.edu.
Steven KiblerNOAA-National Ocean Service, Center for Coastal Fisheries and Habitat Research, Beaufort, NC 28516, USA. steve.kibler@noaa.gov.
Wendy StephanFlorida Poison Information Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. wstephan@med.miami.edu.
Matthew O GribbleDepartment of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA. matt.gribble@emory.edu.
Paul BienfangOceanography Department, University of Hawaii, Honolulu, HI 96822, USA. bienfang@soest.Hawaii.edu.
Robert E BowenSchool for the Environment, University of Massachusetts Boston, Boston, MA 02125, USA. bob.bowen@umb.edu.
Stacey DegrasseFood and Drug Administration, College Park, MD 20740, USA. stacey.degrasse@fda.hhs.gov.
Harold A Flores QuintanaFood and Drug Administration, Dauphin Island, AL 36528, USA. harold.floresquintana@fda.hhs.gov.
Christopher R LoefflerFood and Drug Administration, Dauphin Island, AL 36528, USA. christopher.loeffler@fda.hhs.gov.
Richard WeismanFlorida Poison Information Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA. rweisman@med.miami.edu.
Donna BlythePrivate Practice, Miami, FL 33133, USA. blythedrdiva@aol.com.
Elisa BerdaletInstitut de Ciències del Mar (CSIC), 08003 Barcelona, Spain. berdalet@icm.csic.es.
Ram AyyarDepartment of Neurology, University of Miami, Miami, FL 33136, USA. dayyar@med.miami.edu.
Danielle Clarkson-TownsendDepartment of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA. danielle.clarkson-townsend@emory.edu.
Karen SwajianFood and Drug Administration, College Park, MD 20740, USA. karen.swajian@fda.hhs.gov.
Ronald BennerFood and Drug Administration, Dauphin Island, AL 36528, USA. ronald.benner@fda.hhs.gov.
Tom BrewerNorthern Institute, Charles Darwin University, Darwin 0909, Australia and Australian Institute of Marine Science, Darwin 0811, Australia. tom.brewer@cdu.edu.au.
Lora E FlemingEuropean Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall Tr1 3HD, UK. l.e.fleming@exeter.ac.uk.

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2013 to 2026
$22.6M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
Toxic Harmful Algal Blooms (HABs)P50ES012736 · NIEHS · UNIVERSITY OF MIAMI ROSENTEIL SCHOOL · PI FLEMING, LORA ELDERKIN · 2004 to 2010
$2.7M
NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P50 ES012736NIEHS NIH HHS T32 ES012870NIEHS NIH HHS T32 ES013678
6 · The paper itself

Abstract

Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. This paper is a general review of CFP including the human health effects of exposure to ciguatoxins (CTXs), diagnosis, human pathophysiology of CFP, treatment, detection of CTXs in fish, epidemiology of the illness, global dimensions, prevention, future directions, and recommendations for clinicians and patients. It updates and expands upon the previous review of CFP published by Friedman et al. (2008) and addresses new insights and relevant emerging global themes such as climate and environmental change, international market issues, and socioeconomic impacts of CFP. It also provides a proposed universal case definition for CFP designed to account for the variability in symptom presentation across different geographic regions. Information that is important but unchanged since the previous review has been reiterated. This article is intended for a broad audience, including resource and fishery managers, commercial and recreational fishers, public health officials, medical professionals, and other interested parties.

Indexed as

AnimalsCiguatera PoisoningCiguatoxinsDisease OutbreaksFishesHumansPublic HealthSeafoodCiguatoxinsalgaeciguatera fish poisoningciguatoxinclimate changediagnosisenvironmental changefood poisoningGambierdiscusharmful algal bloomhuman healthnatural toxinsneurologyneuropsychologyneurotoxinseafood poisoningtreatment

Identifiers

PMID28335428
PMCPMC5367029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.