ArticleNanomaterials (Basel, Switzerland)2016
Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption.
Article in Nanomaterials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Organ and tissue accumulation of titanium dioxide after acute, subacute, subchronic, and chronic oral exposure in mice and rats: a systematic review.Particle and fibre toxicology · 2026Pooled it
- Elucidating metabolic dysfunction induced by titanium dioxide in intestinal epithelial cells using an integrative approach of metabolomics and transcriptomics.BMC pharmacology & toxicology · 2026Article
- Comprehensive Evaluation of the Genotoxic Potential of Food Additive Titanium Dioxide in Human Intestinal Cell Systems.International journal of molecular sciences · 2025Article
- Effects of the Interactions Between Food Additive Titanium Dioxide and Matrices on Genotoxicity.International journal of molecular sciences · 2025Article
- Hepatotoxicity of titanium dioxide nanoparticles.Journal of applied toxicology : JAT · 2025Review
- Titanium dioxide nanoparticles Disrupt ultrastructure and function of Rat thyroid tissue via oxidative stress.Heliyon · 2024Article
- Application of nanotechnology in food: processing, preservation, packaging and safety assessment.Heliyon · 2022Review
- Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials.International journal of molecular sciences · 2022Article
- Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles-A Systematic Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Effect of Various Surface Treatments on Wettability and Morphological Properties of Titanium Oxide Thin Films.Materials (Basel, Switzerland) · 2022Article
- Interaction between ZnO Nanoparticles and Albumin and Its Effect on Cytotoxicity, Cellular Uptake, Intestinal Transport, Toxicokinetics, and Acute Oral Toxicity.Nanomaterials (Basel, Switzerland) · 2021Article
- Titanium Dioxide Induces Apoptosis under UVA Irradiation via the Generation of Lysosomal Membrane Permeabilization-Dependent Reactive Oxygen Species in HaCat Cells.Nanomaterials (Basel, Switzerland) · 2021Article
- Influences of a standardized food matrix and gastrointestinal fluids on the physicochemical properties of titanium dioxide nanoparticles.RSC advances · 2021Article
- Establishment of a standardized dietary model for nanoparticles oral exposure studies.Food science & nutrition · 2021Article
- Particle Size and Biological Fate of ZnO Do Not Cause Acute Toxicity, but Affect Toxicokinetics and Gene Expression Profiles in the Rat Livers after Oral Administration.International journal of molecular sciences · 2021Article
- Titanium Dioxide Nanoparticles Induced HeLa Cell Necrosis under UVA Radiation through the ROS-mPTP Pathway.Nanomaterials (Basel, Switzerland) · 2020Article
- Food Additive Titanium Dioxide and Its Fate in Commercial Foods.Nanomaterials (Basel, Switzerland) · 2019Article
- Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure.Particle and fibre toxicology · 2019Article
- A Facile Approach to Fabricate Dual Purpose Hybrid Materials for Tissue Engineering and Water Remediation.Scientific reports · 2019Article
- Protein Food Matrix⁻ZnO Nanoparticle Interactions Affect Protein Conformation, but May not Be Biological Responses.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium dioxide (TiO₂) nanoparticles (NPs) have been widely applied in various industrial fields, such as electronics, packaging, food, and cosmetics. Accordingly, concerns about the potential toxicity of TiO₂ NPs have increased. In order to comprehend their in vivo behavior and potential toxicity, we must evaluate the interactions between TiO₂ NPs and biomolecules, which can alter the physicochemical properties and the fate of NPs under physiological conditions. In the present study, in vivo solubility, oral absorption, tissue distribution, and excretion kinetics of food grade TiO₂ (f-TiO₂) NPs were evaluated following a single-dose oral administration to rats and were compared to those of general grade TiO₂ (g-TiO₂) NPs. The effect of the interactions between the TiO₂ NPs and biomolecules, such as glucose and albumin, on oral absorption was also investigated, with the aim of determining the surface interactions between them. The intestinal transport pathway was also assessed using 3-dimensional culture systems. The results demonstrate that slightly higher oral absorption of f-TiO₂ NPs compared to g-TiO₂ NPs could be related to their intestinal transport mechanism by microfold (M) cells, however, most of the NPs were eliminated through the feces. Moreover, the biokinetics of f-TiO₂ NPs was highly dependent on their interaction with biomolecules, and the dispersibility was affected by modified surface chemistry.
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Registered trials
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