Evidence map›Paper›PMID 28335267›Full record

ReviewNanomaterials (Basel, Switzerland)2016

DNA-Based Enzyme Reactors and Systems.

Veikko Linko, Sami Nummelin, Laura Aarnos, Kosti Tapio, J Jussi Toppari, Mauri A Kostiainen

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Protein Coating of DNA Origami.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Challenges and Perspectives of DNA Nanostructures in Biomedicine.Angewandte Chemie (International ed. in English) · 2020
    Review
  9. Robotic DNA Nanostructures.ACS synthetic biology · 2020
    Review
  10. Article
  11. At the Dawn of Applied DNA Nanotechnology.Molecules (Basel, Switzerland) · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. DNA Origami Nanophotonics and Plasmonics at Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2018
    Article
  16. Review
  17. DNA nanostructure-directed assembly of metal nanoparticle superlattices.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2018
    Review
  18. Metallic Nanostructures Based on DNA Nanoshapes.Nanomaterials (Basel, Switzerland) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Veikko LinkoBiohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, P.O. Box 16100, Aalto 00076, Finland. veikko.linko@aalto.fi.
Sami NummelinBiohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, P.O. Box 16100, Aalto 00076, Finland. sami.nummelin@aalto.fi.
Laura AarnosBiohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, P.O. Box 16100, Aalto 00076, Finland. laura.aarnos@aalto.fi.
Kosti TapioDepartment of Physics, University of Jyvaskyla, Nanoscience Center, P.O. Box 35, Jyväskylä 40014, Finland. kosti.t.o.tapio@jyu.fi.
J Jussi ToppariDepartment of Physics, University of Jyvaskyla, Nanoscience Center, P.O. Box 35, Jyväskylä 40014, Finland. j.jussi.toppari@jyu.fi.
Mauri A KostiainenBiohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, P.O. Box 16100, Aalto 00076, Finland. mauri.kostiainen@aalto.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways. Moreover, sophisticated DNA structures can be utilized in encapsulating active enzymes and delivering the molecular cargo into cells. In this review, we focus on the latest enzyme systems based on novel DNA nanostructures: enzyme reactors, regulatory devices and carriers that can find uses in various biotechnological and nanomedical applications.

Indexed as

cascade reactionsDNA nanodeviceDNA nanotechnologyDNA origamiDNA sensorsdrug-deliveryenzymenanomedicineself-assembly

Identifiers

PMID28335267
PMCPMC5224616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.