Evidence map›Paper›PMID 28335253›Full record

ReviewNanomaterials (Basel, Switzerland)2016

Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery.

Domenico Lombardo, Pietro Calandra, Davide Barreca, Salvatore Magazù, Mikhail A Kiselev

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Domenico LombardoNational Research Council, Institute for Chemical and Physical Processes, Messina 98158, Italy. lombardo@ipcf.cnr.it.
Pietro CalandraNational Research Council, Institute of Nanostructured Materials, Roma 00015, Italy. pietro.calandra@ismn.cnr.it.
Davide BarrecaDepartment of Chemical Sciences, biological, pharmaceutical and environmental, University of Messina, Messina 98166, Italy. dbarreca@unime.it.
Salvatore MagazùDepartment of Physics and Earth Sciences, University of Messina, Messina 98166, Italy. smagazu@unime.it.
Mikhail A KiselevFrank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Moscow 141980, Russia. kiselev@jinr.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by exploiting a combination of a number of suitable soft interactions, can facilitate the transit through the biological barriers from the point of administration up to the site of drug action. As a result, the materials engineer has generated through the bottom up approach a variety of supramolecular nanocarriers for the encapsulation and controlled delivery of therapeutics which have revealed beneficial developments for stabilizing drug compounds, overcoming impediments to cellular and tissue uptake, and improving biodistribution of therapeutic compounds to target sites. Herein we present recent advances in liposome drug delivery by analyzing the main structural features of liposome nanocarriers which strongly influence their interaction in solution. More specifically, we will focus on the analysis of the relevant soft interactions involved in drug delivery processes which are responsible of main behaviour of soft nanocarriers in complex physiological fluids. Investigation of the interaction between liposomes at the molecular level can be considered an important platform for the modeling of the molecular recognition processes occurring between cells. Some relevant strategies to overcome the biological barriers during the drug delivery of the nanocarriers are presented which outline the main structure-properties relationships as well as their advantages (and drawbacks) in therapeutic and biomedical applications.

Indexed as

drug deliveryliposomesnanotechnologyphospholipids vesicles systems

Identifiers

PMID28335253
PMCPMC5224599

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.