ArticleNanomaterials (Basel, Switzerland)2016
Selective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes.
Article in Nanomaterials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Functionalized Nanodiamonds for Targeted Neuronal Electromagnetic Signal Detection.ACS applied materials & interfaces · 2024Article
- Monitoring spin coherence of single nitrogen-vacancy centers in nanodiamonds during pH changes in aqueous buffer solutions.RSC advances · 2019Article
- Fluorescent Nanodiamond Applications for Cellular Process Sensing and Cell Tracking.Micromachines · 2018Review
- Varying temperature and silicon content in nanodiamond growth: effects on silicon-vacancy centres.Scientific reports · 2018Article
- Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions.Journal of controlled release : official journal of the Controlled Release Society · 2017Review
- The interaction of fluorescent nanodiamond probes with cellular media.Mikrochimica acta · 2017Article
- Nanoparticles in Bioimaging.Nanomaterials (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impeccable photostability of fluorescent nanodiamonds (FNDs) is an ideal property for use in fluorescence imaging of proteins in living cells. However, such an application requires highly specific labeling of the target proteins with FNDs. Furthermore, the surface of unmodified FNDs tends to adsorb biomolecules nonspecifically, which hinders the reliable targeting of proteins with FNDs. Here, we combined hyperbranched polyglycerol modification of FNDs with the β-lactamase-tag system to develop a strategy for selective imaging of the protein of interest in cells. The combination of these techniques enabled site-specific labeling of Interleukin-18 receptor alpha chain, a membrane receptor, with FNDs, which eventually enabled tracking of the diffusion trajectory of FND-labeled proteins on the membrane surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.