ArticleRedox biology2017
Biochemical signaling by remote ischemic conditioning of the arm versus thigh: Is one raise of the cuff enough?
Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Remote ischemic conditioning combined with transcutaneous vagus nerve stimulation reduces reperfusion injuries and improves cardiac function in acute ST-segment elevation myocardial infarctions.BMC cardiovascular disorders · 2026Trial
- Remote ischemic conditioning improves neuropsychiatric symptoms in COVID-19 patients: a randomized clinical trial.Frontiers in psychiatry · 2025Trial
- Trial
- Effects of remote ischemic preconditioning on coronary blood flow and microcirculation.BMC cardiovascular disorders · 2023Trial
- Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial.Scientific reports · 2023Trial
- Vascular conditioning prevents adverse left ventricular remodelling after acute myocardial infarction: a randomised remote conditioning study.Basic research in cardiology · 2021Trial
- Effect of COMBinAtion therapy with remote ischemic conditioning and exenatide on the Myocardial Infarct size: a two-by-two factorial randomized trial (COMBAT-MI).Basic research in cardiology · 2021Trial
- Two weeks of remote ischemic conditioning improves brachial artery flow mediated dilation in chronic stroke survivors.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Declines in exercise performance are prevented 24 hours after post-exercise ischemic conditioning in amateur cyclists.PloS one · 2018Trial
- Hemodynamic effects of IV sodium nitrite in hospitalized comatose survivors of out of hospital cardiac arrest.Resuscitation · 2018Trial
- Does Exsanguination Enhance Skin Microcirculation in Remote Ischemic Conditioning Using a Tourniquet? A Randomized Controlled Trial on 50 Healthy Subjects.Archives of plastic surgery · 2026Article
- Research progress on remote ischemic conditioning for improving prognosis of patients with acute ischemic stroke.Biochemistry and biophysics reports · 2025Review
- Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia-From Modern Therapeutics to Traditional Chinese Medicine.Aging and disease · 2025Review
- Remote but not Distant: a Review on Experimental Models and Clinical Trials in Remote Ischemic Conditioning as Potential Therapy in Ischemic Stroke.Molecular neurobiology · 2022Review
- Myocardial remote ischemic preconditioning: from cell biology to clinical application.Molecular and cellular biochemistry · 2021Review
- Remote ischaemic conditioning for stroke: unanswered questions and future directions.Stroke and vascular neurology · 2021Review
- Therapeutic Potential of Remote Ischemic Conditioning in Vascular Cognitive Impairment.Frontiers in cellular neuroscience · 2021Review
- Sex differences in fatigability after ischemic preconditioning of non-exercising limbs.Biology of sex differences · 2020Article
- Platelet glycolytic metabolism correlates with hemodynamic severity in pulmonary arterial hypertension.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Blood-based bioenergetics: An emerging translational and clinical tool.Molecular aspects of medicine · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Remote Ischemic Conditioning (RIC), induced by brief cycles of ischemia and reperfusion, protects vital organs from a prolonged ischemic insult. While several biochemical mediators have been implicated in RIC's mechanism of action, it remains unclear whether the localization or "dose" of RIC affects the extent of protective signaling. In this randomized crossover study of healthy individuals, we tested whether the number of cycles of RIC and its localization (arm versus thigh) determines biochemical signaling and cytoprotection. Subjects received either arm or thigh RIC and then were crossed over to receive RIC in the other extremity. Blood flow, tissue perfusion, concentrations of the circulating protective mediator nitrite, and platelet mitochondrial function were measured after each RIC cycle. We found that plasma nitrite concentration peaked after the first RIC cycle and remained elevated throughout RIC. This plasma nitrite conferred cytoprotection in an in vitro myocyte model of hypoxia/reoxygenation. Notably, though plasma nitrite returned to baseline at 24h, RIC conditioned plasma still mediated protection. Additionally, no difference in endpoints between RIC in thigh versus arm was found. These data demonstrate that localization and "dose" of RIC does not affect cytoprotection and further elucidate the mechanisms by which nitrite contributes to RIC-dependent protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.