Evidence map›Paper›PMID 28334511›Full record

ArticleChemMedChem2017

Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin.

Kornelia Hardes, Teodora Ivanova, Bastian Thaa, Gerald M McInerney, Tove Irene Klokk, Kirsten Sandvig, Sebastian Künzel, Iris Lindberg, Torsten Steinmetzer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Repurposing of Furin Inhibitors to Reduce PathogenicAntibiotics (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Development and Prospects of Furin Inhibitors for Therapeutic Applications.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Kornelia HardesInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032, Marburg, Germany), Fax: (+49) 642-128-259-01.
Teodora IvanovaInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032, Marburg, Germany), Fax: (+49) 642-128-259-01.
Bastian ThaaKarolinska Institutet, Department of Microbiology, Tumor and Cell Biology, 171 77, Stockholm, Sweden.
Gerald M McInerneyKarolinska Institutet, Department of Microbiology, Tumor and Cell Biology, 171 77, Stockholm, Sweden.
Tove Irene KlokkDepartment of Molecular Cell Biology and Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway.
Kirsten SandvigDepartment of Molecular Cell Biology and Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway.
Sebastian KünzelFaculty of Engineering Sciences, Hochschule Ansbach, Residenzstraße 8, 91522, Ansbach, Germany.
Iris LindbergDepartment of Anatomy and Neurobiology, University of Maryland Medical School, Baltimore, MD, 21201, USA.
Torsten SteinmetzerInstitute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032, Marburg, Germany), Fax: (+49) 642-128-259-01.ORCID 0000-0001-6523-4754
Philipps University of Marburg · DEKarolinska Institutet · SENorwegian Cancer Society · NOAnsbach University of Applied Sciences · DEUniversity of Maryland, Baltimore · US

Funding

OPIOID PEPTIDE SYNTHESIZING ENZYMESR01DA005084 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDBERG, IRIS · 1988 to 2014
$4.4M
Opioid Peptide Synthesizing EnzymesR01DA042351 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDBERG, IRIS · 2017 to 2021
$2.0M
Opioid Peptide Synthesizing EnzymesR56DA005084 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDBERG, IRIS · 2016 to 2016
$174k
NIDA NIH HHS R01 DA005084NIDA NIH HHS R01 DA042351NIDA NIH HHS R56 DA005084
6 · The paper itself

Abstract

Novel elongated and shortened derivatives of the peptidomimetic furin inhibitor phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide were synthesized. The most potent compounds, such as N

Indexed as

AnimalsAntiviral AgentsBenzamidesCell LineChikungunya virusChlorocebus aethiopsCricetinaeDiphtheria ToxinFurinOligopeptidesPeptidomimeticsSemliki forest virusSerine Proteinase InhibitorsAntiviral AgentsBenzamidesDiphtheria ToxinFurinOligopeptidesPeptidomimeticsSerine Proteinase Inhibitorsalphaviruseschikungunya virusdiphtheria toxinfurininhibitorsSemliki Forest virus

Identifiers

PMID28334511
PMCPMC5572662
OpenAlexW2601371130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.