Evidence map›Paper›PMID 28334392›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2017

Validation of the NIH Toolbox in Individuals with Neurologic Disorders.

N E Carlozzi, S Goodnight, K B Casaletto, A Goldsmith, R K Heaton, A W K Wong, C M Baum, R Gershon, A W Heinemann, D S Tulsky

Abstract readValidation Study
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Cognitive Correlates of Resilience in Adults Experiencing Homelessness.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
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  10. Review
  11. Article
  12. Article
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  19. Article
  20. Validity of the NIH toolbox cognitive battery in a healthy oldest-old 85+ sample.Journal of the International Neuropsychological Society : JINS · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

N E CarlozziDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.
S GoodnightDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48109, USA.
K B CasalettoDepartment of Neurology, University of California, San Francisco, CA 94122, USA.
A GoldsmithCenter for Rehabilitation Outcomes Research, Rehabilitation Institute of Chicago, Chicago, IL 60611, USA.
R K HeatonDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
A W K WongOccupational Therapy and Department of Neurology, Washington University, St. Louis, MO 63108, USA.
C M BaumOccupational Therapy and Department of Neurology, Washington University, St. Louis, MO 63108, USA.
R GershonDepartment of Medical Social Sciences, Northwestern University, Chicago, IL 60611, USA.
A W HeinemannCenter for Rehabilitation Outcomes Research, Rehabilitation Institute of Chicago, Chicago, IL 60611, USA.
D S TulskyDepartment of Physical Therapy, Center for Assessment Research and Translation, University of Delaware, Newark, DE 19713, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
The National Person-Centered Assessment Resource (PCAR)U2CCA186878 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CELLA, DAVID · 2014 to 2018
$11.9M
A Metacognition-based Approach to Improve HAND Among Methamphetamine UsersF31DA035708 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CASALETTO, KAITLIN B · 2013 to 2015
$99k
NCI NIH HHS U2C CA186878NIDA NIH HHS F31 DA035708NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

objectiveIndividuals with spinal cord injury (SCI), traumatic brain injury (TBI), and stroke experience a variety of neurologically related deficits across multiple domains of function. The NIH Toolbox for the Assessment of Neurological and Behavioral Function (NIHTB) examines motor, sensation, cognition, and emotional functioning. The purpose of this paper is to establish the validity of the NIHTB in individuals with neurologic conditions.

methodsCommunity-dwelling individuals with SCI (n = 209), TBI (n = 184), or stroke (n = 211) completed the NIHTB. Relative risks for impaired performance were examined relative to a matched control groups.

resultsThe largest group differences were observed on the Motor domain and for the Fluid Cognition measures. All groups were at increased risk for motor impairment relative to normative standards and matched controls. Fluid cognitive abilities varied across groups such that individuals with stroke and TBI performed more poorly than individuals with SCI; increased relative risks for impaired fluid cognition were seen for individuals in the stroke and TBI groups, but not for those in the SCI group. All three neurologic groups performed normally on most measures in the Sensation Battery, although TBI participants evidenced increased risk for impaired odor identification and the stroke group showed more vision difficulties. On the Emotion Battery, participants in all three groups showed comparably poor psychological well-being, social satisfaction, and self-efficacy, whereas the TBI group also evidenced slightly increased negative affect.

conclusionsData provide support for the validity of the NIHTB in individuals with neurologic conditions.

Indexed as

Social BehaviorAdultAffective SymptomsAgedBrain Injuries, TraumaticCognitive DysfunctionDiagnostic Techniques, NeurologicalFemaleHumansMaleMiddle AgedMovement DisordersNational Institutes of Health (U.S.)Neuropsychological TestsPsychiatric Status Rating ScalesReproducibility of ResultsAssessmentCognitionDisabilityEmotionMotorNIHTBOutcomes assessment (health care)SensorySpinal cord injuryStrokeTraumatic brain injury

Identifiers

PMID28334392
PMCPMC5860275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.