ArticleCerebral cortex (New York, N.Y. : 1991)2018
A Critical Role of Inhibition in Temporal Processing Maturation in the Primary Auditory Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- Article
- Article
- The neuronal and synaptic representations of spatial release from masking in the rat auditory cortex.Frontiers in neuroscience · 2025Article
- Sex differences during development in cortical temporal processing and event related potentials in wild-type and fragile X syndrome model mice.Journal of neurodevelopmental disorders · 2024Article
- Whole-Brain Direct Inputs to and Axonal Projections from Excitatory and Inhibitory Neurons in the Mouse Primary Auditory Area.Neuroscience bulletin · 2022Article
- The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles.The European journal of neuroscience · 2021Review
- Plasticity of Multidimensional Receptive Fields in Core Rat Auditory Cortex Directed by Sound Statistics.Neuroscience · 2021Article
- Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex.Frontiers in neuroscience · 2021Article
- Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance.Neuron · 2020Article
- Effects of Gap Position on Perceptual Gap Detection Across Late Childhood and Adolescence.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Preserving Inhibition during Developmental Hearing Loss Rescues Auditory Learning and Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Late maturation of backward masking in auditory cortex.Journal of neurophysiology · 2018Article
- Early impoverished environment delays the maturation of cerebral cortex.Scientific reports · 2018Article
- Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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12 authors.
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Abstract
Faithful representation of sound envelopes in primary auditory cortex (A1) is vital for temporal processing and perception of natural sounds. However, the emergence of cortical temporal processing mechanisms during development remains poorly understood. Although cortical inhibition has been proposed to play an important role in this process, direct in-vivo evidence has been lacking. Using loose-patch recordings in rat A1 immediately after hearing onset, we found that stimulus-following ability in fast-spiking neurons was significantly better than in regular-spiking (RS) neurons. In-vivo whole-cell recordings of RS neurons revealed that inhibition in the developing A1 demonstrated much weaker adaptation to repetitive stimuli than in adult A1. Furthermore, inhibitory synaptic inputs were of longer duration than observed in vitro and in adults. Early in development, overlap of the prolonged inhibition evoked by 2 closely following stimuli disrupted the classical temporal sequence between excitation and inhibition, resulting in slower following capacity. During maturation, inhibitory duration gradually shortened accompanied by an improving temporal following ability of RS neurons. Both inhibitory duration and stimulus-following ability demonstrated exposure-based plasticity. These results demonstrate the role of inhibition in setting the pace for experience-dependent maturation of temporal processing in the auditory cortex.
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