ArticleCerebral cortex (New York, N.Y. : 1991)2017
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Translational psychiatry · 2026Pooled it
- Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders.Biological psychiatry · 2023Pooled it
- Neural correlates of socioeconomic status in early childhood: a systematic review of the literature.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Pooled it
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Risk of Depression in the Adolescent and Adult Offspring of Mothers With Perinatal Depression: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Postnatal distress, neonatal cerebellar myelination and neurodevelopmental outcomes at 18 months.Molecular psychiatry · 2026Article
- A Longitudinal Study of Children's Hippocampal Development: Investigating Maternal Physical Activity, Depression, and Education.Developmental neurobiology · 2026Article
- Adrenarche as a regulator of sensitivity to early adversity.Journal of neuroendocrinology · 2026Review
- The association between prenatal maternal anxiety, infant brain volumes, and temperament during the COVID-19 pandemic.Translational psychiatry · 2025Article
- Prenatal Antidepressant Exposure and the Developing Brain: A Review of Neuroimaging Findings.Current topics in behavioral neurosciences · 2025Review
- Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development.Pediatric research · 2024Review
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium.Developmental psychobiology · 2024Article
- Childhood socioeconomic status and the pace of structural neurodevelopment: accelerated, delayed, or simply different?Trends in cognitive sciences · 2023Review
- Prenatal programming of environmental sensitivity.Translational psychiatry · 2023Review
- Prenatal depressive symptoms and childhood development of brain limbic and default mode network structure.Human brain mapping · 2023Article
- Association of Maternal Depression During Pregnancy and Recent Stress With Brain Age Among Adult Offspring.JAMA network open · 2023Article
- Identification of eQTLs and differential gene expression associated with fetal programming in beef cattle.Journal of applied genetics · 2022Article
- Maternal depressive symptoms, neonatal white matter, and toddler social-emotional development.Translational psychiatry · 2022Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 4 countries.
Funding
Abstract
This study included 168 and 85 mother-infant dyads from Asian and United States of America cohorts to examine whether a genomic profile risk score for major depressive disorder (GPRSMDD) moderates the association between antenatal maternal depressive symptoms (or socio-economic status, SES) and fetal neurodevelopment, and to identify candidate biological processes underlying such association. Both cohorts showed a significant interaction between antenatal maternal depressive symptoms and infant GPRSMDD on the right amygdala volume. The Asian cohort also showed such interaction on the right hippocampal volume and shape, thickness of the orbitofrontal and ventromedial prefrontal cortex. Likewise, a significant interaction between SES and infant GPRSMDD was on the right amygdala and hippocampal volumes and shapes. After controlling for each other, the interaction effect of antenatal maternal depressive symptoms and GPRSMDD was mainly shown on the right amygdala, while the interaction effect of SES and GPRSMDD was mainly shown on the right hippocampus. Bioinformatic analyses suggested neurotransmitter/neurotrophic signaling, SNAp REceptor complex, and glutamate receptor activity as common biological processes underlying the influence of antenatal maternal depressive symptoms on fetal cortico-limbic development. These findings suggest gene-environment interdependence in the fetal development of brain regions implicated in cognitive-emotional function. Candidate biological mechanisms involve a range of brain region-specific signaling pathways that converge on common processes of synaptic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.