ArticleCerebral cortex (New York, N.Y. : 1991)2018
Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
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- Digital Atlases to Unlock the Potential of Brain Biorepository Tissues for Interdisciplinary Research.bioRxiv : the preprint server for biology · 2026Article
- Brain morphology in Anorexia Nervosa and its subtypes: A multi-cohort study of individual participant data.PLoS medicine · 2026Article
- Repurposing medications to prevent psychosis.Npj mental health research · 2025Review
- Sex differences in normative modeling of cortical thickness in cannabis use disorder.Drug and alcohol dependence reports · 2025Article
- COVID-19 lockdown effects on adolescent brain structure suggest accelerated maturation that is more pronounced in females than in males.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Regional patterns of human cortex development correlate with underlying neurobiology.Nature communications · 2024Article
- Regional patterns of human cortex development correlate with underlying neurobiology.bioRxiv : the preprint server for biology · 2024Article
- General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.Human brain mapping · 2024Article
- General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning.bioRxiv : the preprint server for biology · 2023Article
- Life Event Stress and Reduced Cortical Thickness in Youth at Clinical High Risk for Psychosis and Healthy Control Subjects.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Assessment of Neurobiological Mechanisms of Cortical Thinning During Childhood and Adolescence and Their Implications for Psychiatric Disorders.JAMA psychiatry · 2020Article
- Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth.Transgender health · 2020Article
- Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor?Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Cell-Specific Gene-Expression Profiles and Cortical Thickness in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Long-term impacts of prenatal synthetic glucocorticoids exposure on functional brain correlates of cognitive monitoring in adolescence.Scientific reports · 2018Article
- Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex.NeuroImage · 2018Article
- Early adversity and brain response to faces in young adulthood.Human brain mapping · 2017Article
- Income inequality, gene expression, and brain maturation during adolescence.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Age-related decreases in cortical thickness observed during adolescence may be related to fluctuations in sex and stress hormones. We examine this possibility by relating inter-regional variations in age-related cortical thinning (data from the Saguenay Youth Study) to inter-regional variations in expression levels of relevant genes (data from the Allen Human Brain Atlas); we focus on genes coding for glucocorticoid receptor (NR3C1), androgen receptor (AR), progesterone receptor (PGR), and estrogen receptors (ESR1 and ESR2). Across 34 cortical regions (Desikan-Killiany parcellation), age-related cortical thinning varied as a function of mRNA expression levels of NR3C1 in males (R2 = 0.46) and females (R2 = 0.30) and AR in males only (R2 = 0.25). Cortical thinning did not vary as a function of expression levels of PGR, ESR1, or ESR2 in either sex; this might be due to the observed low consistency of expression profiles of these 3 genes across donors. Inter-regional levels of the NR3C1 and AR expression interacted with each other vis-à-vis cortical thinning: age-related cortical thinning varied as a function of NR3C1 mRNA expression in brain regions with low (males: R2 = 0.64; females: R2 = 0.58) but not high (males: R2 = 0.0045; females: R2 = 0.15) levels of AR mRNA expression. These results suggest that glucocorticoid and androgen receptors contribute to cortical maturation during adolescence.
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