ArticleCerebral cortex (New York, N.Y. : 1991)2017
Layer-Specific Organization of Local Excitatory and Inhibitory Synaptic Connectivity in the Rat Presubiculum.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex.Pflugers Archiv : European journal of physiology · 2026Article
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- Electrophysiological classification of human layer 2-3 pyramidal neurons reveals subtype-specific synaptic interactions.Nature neuroscience · 2026Article
- Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026Article
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- Augmenting flexibility: mutual inhibition between inhibitory neurons expands functional diversity.iScience · 2025Article
- Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity.Neuroscience bulletin · 2024Review
- Hippocampal GABAergic interneurons and memory.Neuron · 2023Review
- Local production of corticotropin-releasing hormone in prefrontal cortex modulates male-specific novelty exploration.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition.PLoS computational biology · 2022Article
- Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson's disease in rodent models.Experimental neurology · 2022Review
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Role of Lateral Inhibition on Visual Number Sense.Frontiers in computational neuroscience · 2022Article
- Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Spatially structured inhibition defined by polarized parvalbumin interneuron axons promotes head direction tuning.Science advances · 2021Article
- Molecular Characterization of Superficial Layers of the Presubiculum During Development.Frontiers in neuroanatomy · 2021Article
- Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons.Frontiers in synaptic neuroscience · 2020Review
- Article
- Article
- Electrophysiological and Molecular Characterization of the Parasubiculum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presubiculum is part of the parahippocampal spatial navigation system and contains head direction and grid cells upstream of the medial entorhinal cortex. This position within the parahippocampal cortex renders the presubiculum uniquely suited for analyzing the circuit requirements underlying the emergence of spatially tuned neuronal activity. To identify the local circuit properties, we analyzed the topology of synaptic connections between pyramidal cells and interneurons in all layers of the presubiculum by testing 4250 potential synaptic connections using multiple whole-cell recordings of up to 8 cells simultaneously. Network topology showed layer-specific organization of microcircuits consistent with the prevailing distinction of superficial and deep layers. While connections among pyramidal cells were almost absent in superficial layers, deep layers exhibited an excitatory connectivity of 3.9%. In contrast, synaptic connectivity for inhibition was higher in superficial layers though markedly lower than in other cortical areas. Finally, synaptic amplitudes of both excitatory and inhibitory connections showed log-normal distributions suggesting a nonrandom functional connectivity. In summary, our study provides new insights into the microcircuit organization of the presubiculum by revealing area- and layer-specific connectivity rules and sets new constraints for future models of the parahippocampal navigation system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.