ArticlePloS one2017
Surgical interventions to treat humerus shaft fractures: A network meta-analysis of randomized controlled trials.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Systematic review of humeral shaft fracture (OTA/AO 12) complicated with iatrogenic radial nerve injury.European journal of medical research · 2024Pooled it
- Humeral shaft fracture: systematic review of non-operative and operative treatment.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Antegrade intramedullary nail versus plate fixation in the treatment of humeral shaft fractures: An update meta-analysis.Medicine · 2019Pooled it
- Trial
- Factors associated with humeral shaft fracture nonunion.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Review
- Outcomes of intramedullary nailing versus plate fixation for humeral shaft fractures: a retrospective cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- A Bibliometric Analysis of the Top 50 Most Cited Articles on Iatrogenic Nerve Injuries of the Upper Limb Following Surgery.Journal of brachial plexus and peripheral nerve injury · 2025Review
- Open Reduction and Internal Fixation with Bone Morphogenetic Protein-2 for Correction of Nonunion Humeral Shaft Fracture with Pseudoarthrosis in the Geriatric Population: A Case Report.Journal of orthopaedic case reports · 2024Article
- In cases of humeral diaphyseal fractures, is lateral approach surgery without radial nerve exploration as effective and safe as conventional surgery?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Helical Plating Compared with Straight Plating and Nailing for Treatment of Proximal Third Humeral Shaft Fractures-A Biomechanical Study.Medicina (Kaunas, Lithuania) · 2023Article
- Humerus shaft fractures, approaches and management.Journal of clinical orthopaedics and trauma · 2023Review
- Treatment of humeral shaft fractures with different treatment methods: a network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2023Article
- Outcome and complication comparison for intramedullary nail versus open reduction internal fixation in humeral diaphyseal fractures for 2800 matched patient pairs utilizing the Nationwide Readmissions Database.Journal of orthopaedic surgery and research · 2023Article
- HUMERAL SHAFT FRACTURE WITH AN INTACT WEDGE FRAGMENT: MIPO VS CONVENTIONAL PLATING.Acta ortopedica brasileira · 2023Article
- Percutaneous Intramedullary Nailing of Complex Humeral Shaft Fractures: A Retrospective Case Series.Cureus · 2022Article
- Fragility of statistically significant findings from randomized clinical trials of surgical treatment of humeral shaft fractures: A systematic review.World journal of orthopedics · 2022Article
- Intramedullary Nailing Versus Plate Fixation for Humeral Shaft Fractures: A Systematic Review and Meta-Analysis.The archives of bone and joint surgery · 2022Review
- The management of displaced humeral shaft fractures - A survey of UK shoulder and elbow surgeons.Shoulder & elbow · 2022Article
- Complications in humeral shaft fractures - non-union, iatrogenic radial nerve palsy, and postoperative infection: a systematic review and meta-analysis.EFORT open reviews · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are three main surgical techniques to treat humeral shaft fractures: open reduction and plate fixation (ORPF), intramedullary nail (IMN) fixation, and minimally invasive percutaneous osteosynthesis (MIPO). We performed a network meta-analysis to compare three surgical procedures, including ORPF, IMN fixation, and MIPO, to provide the optimum treatment for humerus shaft fractures.
methodsMEDLINE, EMBASE, Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, and Cochrane library were researched for reports published up to May 2016. We only included randomized controlled trials (RCTs) comparing two or more of the three surgical procedures, including the ORPF, IMN, and MIPO techniques, for humeral shaft fractures in adults. The methodological quality was evaluated based on the Cochrane risk of bias tool. We used WinBUGS1.4 to conduct this Bayesian network meta-analysis. We used the odd ratios (ORs) with 95% confidence intervals (CIs) to calculate the dichotomous outcomes and analyzed the percentages of the surface under the cumulative ranking curve.
resultsSeventeen eligible publications reporting 16 RCTs were included in this study. Eight hundred and thirty-two participants were randomized to receive one of three surgical procedures. The results showed that shoulder impingement occurred more commonly in the IMN group than with either ORPF (OR, 0.13; 95% CI, 0.03-0.37) or MIPO fixation (OR, 0.08; 95% CI, 0.00-0.69). Iatrogenic radial nerve injury occurred more commonly in the ORPF group than in the MIPO group (OR, 11.09; 95% CI, 1.80-124.20). There were no significant differences among the three procedures in nonunion, delayed union, and infection.
conclusionCompared with IMN and ORPF, MIPO technique is the preferred treatment method for humeral shaft fractures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.