ArticleGenetics in medicine : official journal of the American College of Medical Genetics2017
Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 6 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A Systematic Review on the Genetic Contribution to Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2024Pooled it
- Genetic architecture distinguishes tinnitus from hearing loss.Nature communications · 2024Pooled it
- Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2023Pooled it
- Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis.Journal of the Association for Research in Otolaryngology : JARO · 2023Pooled it
- Pooled it
- The Relationship of Tinnitus Distress With Personality Traits: A Systematic Review.Frontiers in neurology · 2020Pooled it
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Interactive Effects of Occupational Hearing Loss and Glutathion S-Transferase M1 Genotype on Tinnitus Among Noise-exposed Steelworkers.Safety and health at work · 2026Article
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus.medRxiv : the preprint server for health sciences · 2025Article
- A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Greenness, Genetic Predisposition, and Tinnitus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Development, Insults and Predisposing Factors of the Brain's Predictive Coding System to Chronic Perceptual Disorders-A Life-Course Examination.Brain sciences · 2024Article
- Transcriptional-profile changes in the medial geniculate body after noise-induced tinnitus.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Article
- An MR spectroscopy study of temporal areas excluding primary auditory cortex and frontal regions in subjective bilateral and unilateral tinnitus.Scientific reports · 2023Article
- Current and Emerging Therapies for Chronic Subjective Tinnitus.Journal of clinical medicine · 2023Review
- A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders.Scientific reports · 2022Article
- Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus.NPJ genomic medicine · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGenetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR).
methodsCross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures.
resultsStratification of tinnitus cases into subtypes according to laterality (unilateral versus bilateral) revealed that heritability of bilateral tinnitus was 0.56; however, it was 0.27 for unilateral tinnitus. Heritability was greater in men (0.68) than in women (0.41). However, when female pairs younger than 40 years of age were selected, heritability of 0.62 was achieved with negligible effects of shared environment.
conclusionUnlike unilateral tinnitus, bilateral tinnitus is influenced by genetic factors and might constitute a genetic subtype. Overall, our study provides the initial evidence for a tinnitus phenotype with a genetic influence.Genet Med advance online publication 23 March 2017.
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