ArticleCritical care medicine2017
Antibiotic-Associated Apoptotic Enterocolitis in the Absence of a Defined Pathogen: The Role of Intestinal Microbiota Depletion.
Article in Critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Lower gastrointestinal tract dysbiosis in persistent critical illness: a systematic review.Journal of medical microbiology · 2024Pooled it
- Trial
- Neglected Joint Infection Occurring Following Intra-Articular Injection and Colon Perforation: A Case Report.Case reports in orthopedics · 2026Article
- The gastrointestinal microbiome in critical illness: A Clinician's guide to mechanisms, emerging tools, and therapeutic questions.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- Targeting Gut-Lung Crosstalk in Acute Respiratory Distress Syndrome: Exploring the Therapeutic Potential of Fecal Microbiota Transplantation.Pathogens (Basel, Switzerland) · 2025Review
- Hypothesized mechanism of amelioration of colitis by Clostridium butyricum as a hydrogen-producing bacterium.Medical gas research · 2024Article
- Review
- Effects of antibiotic cocktail on the fecal microbiota and their potential correlation of local immune response.BMC microbiology · 2024Article
- Gut-derived immune cells and the gut-lung axis in ARDS.Critical care (London, England) · 2024Review
- Safety and efficacy of fecal microbiota transplantation (FMT) as a modern adjuvant therapy in various diseases and disorders: a comprehensive literature review.Frontiers in immunology · 2024Review
- Protective effect of gut microbiota restored by fecal microbiota transplantation in a sepsis model in juvenile mice.Frontiers in immunology · 2024Article
- Gut Microbiota and Critically Ill Patients: Immunity and Its Modulation via Probiotics and Immunonutrition.Nutrients · 2023Review
- The role of the microbiota in the management of intensive care patients.Annals of intensive care · 2022Review
- Fecal Microbial Transplantation in Critically Ill Patients-Structured Review and Perspectives.Biomolecules · 2021Review
- Gut Microbiota and Probiotics/Synbiotics for Modulation of Immunity in Critically Ill Patients.Nutrients · 2021Review
- Antibiotics Modulate Intestinal Regeneration.Biology · 2021Article
- The use of fecal microbiota transplant in sepsis.Translational research : the journal of laboratory and clinical medicine · 2020Review
- [Autoimmune enteropathy in adults : A rare and difficult but relevant differential diagnosis of chronic diarrhea].Der Pathologe · 2020Article
- Review
- Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients.Critical care (London, England) · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAntibiotic therapy is a major risk factor for the development of diarrhea and colitis with varying severity. Often the origin of antibiotic-associated gastrointestinal deterioration remains elusive and no specific infectious agents could be discerned. PATIENTS: We represent three cases of intractable high-volume diarrhea associated with combined antibiotic and steroid therapy in critically ill patients not fitting into established disease entities. Cases presented with severe apoptotic enterocolitis resembling acute intestinal graft-versus-host-disease. Microbiologic workup precluded known enteropathogens, but microbiota analysis revealed a severely depleted gut microbiota with concomitant opportunistic pathogen overgrowth.
interventionsFecal microbiota transplantation, performed in one patient, was associated with correction of dysbiosis, rapid clinical improvement, and healing of enterocolitis.
conclusionsOur series represents a severe form of antibiotic-associated colitis in critically ill patients signified by microbiota depletion, and reestablishment of a physiologic gastrointestinal microbiota might be beneficial for this condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.