ArticleIEEE transactions on medical imaging2017
Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography.
Article in IEEE transactions on medical imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Multispectral Laser-Scanning Photoacoustic Microscopy With SRS-Generated Wavelengths for Skin Chromophore Characterization.Journal of biophotonics · 2026Article
- Multimodal fluorescence-optoacousticPhotoacoustics · 2025Article
- Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.Nature communications · 2024Article
- Spiral scanning and self-supervised image reconstruction enable ultra-sparse sampling multispectral photoacoustic tomography.Photoacoustics · 2024Article
- Multispectral Optoacoustic Tomography Enables In Vivo Anatomical and Functional Assessment of Human Tendons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion.Photoacoustics · 2023Article
- Multimodal assessment of non-alcoholic fatty liver disease with transmission-reflection optoacoustic ultrasound.Theranostics · 2023Article
- Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.European journal of nuclear medicine and molecular imaging · 2022Article
- Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast.Journal of biomedical optics · 2022Article
- Multi-scale optoacoustic molecular imaging of brain diseases.European journal of nuclear medicine and molecular imaging · 2021Review
- Advanced Ultrasound and Photoacoustic Imaging in Cardiology.Sensors (Basel, Switzerland) · 2021Review
- Optoacoustic Imaging of Glucagon-like Peptide-1 Receptor with a Near-Infrared Exendin-4 Analog.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
- Breaking the resolution limit in photoacoustic imaging using non-negativity and sparsity.Photoacoustics · 2020Article
- Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry.Journal of biomedical optics · 2019Article
- Unmixing multi-spectral photoacoustic sources in human carotid plaques using non-negative independent component analysis.Photoacoustics · 2019Article
- Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.Light, science & applications · 2019Article
- Noninvasive Anatomical and Functional Imaging of Orthotopic Glioblastoma Development and Therapy using Multispectral Optoacoustic Tomography.Translational oncology · 2018Article
- Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer.Chemical science · 2018Article
- Absolute Quantitative Photoacoustic Imaging for Contrast Agents Concentration Estimation Using a Spectral Decomposition Approach.Molecular imagingArticle
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6 authors.
Funding
Abstract
Accurate extraction of physical and biochemical parameters from optoacoustic images is often impeded due to the use of unrigorous inversion schemes, incomplete tomographic detection coverage, or other experimental factors that cannot be readily accounted for during the image acquisition and reconstruction process. For instance, inaccurate assumptions in the physical forward model may lead to negative optical absorption values in the reconstructed images. Any artifacts present in the single wavelength optoacoustic images can be significantly aggravated when performing a two-step reconstruction consisting in acoustic inversion and spectral unmixing aimed at rendering the distributions of spectrally distinct absorbers. We investigate a number of algorithmic strategies with non-negativity constraints imposed at the different phases of the reconstruction process. Performance is evaluated in cross-sectional multispectral optoacoustic tomography recordings from tissue-mimicking phantoms and in vivo mice embedded with varying concentrations of contrast agents. Additional in vivo validation is subsequently performed with molecular imaging data involving subcutaneous tumors labeled with genetically expressed iRFP proteins and organ perfusion by optical contrast agents. It is shown that constrained reconstruction is essential for reducing the critical image artifacts associated with inaccurate modeling assumptions. Furthermore, imposing the non-negativity constraint directly on the unmixed distribution of the probe of interest was found to maintain the most robust and accurate reconstruction performance in all experiments.
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