Evidence map›Paper›PMID 28333376›Full record

ReviewComprehensive Physiology2017

Regulation of Coronary Blood Flow.

Adam G Goodwill, Gregory M Dick, Alexander M Kiel, Johnathan D Tune

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 2 syntheses or guidelines pooled it, 294 citations in OpenAlex.

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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Adam G GoodwillDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Gregory M DickCalifornia Medical Innovations Institute, 872 Towne Center Drive, Pomona, CA.
Alexander M KielDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Johnathan D TuneDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
Indiana University – Purdue University Indianapolis · USCalifornia Medical Innovations Institute · USIndiana University School of Medicine

Funding

Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Coronary Blood Flow: Integrated Theory and ExperimentsU01HL118738 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A, KASSAB, GHASSAN S · 2013 to 2018
$3.4M
Interdisciplinary Bioengineering Training in Diabetes ResearchT32DK101001 · NIDDK · PURDUE UNIVERSITY · PI EVANS-MOLINA, CARMELLA, VOYTIK-HARBIN, SHERRY L · 2013 to 2022
$1.6M
NHLBI NIH HHS U01 HL118738NIDDK NIH HHS T32 DK101001NIGMS NIH HHS T32 GM077229
6 · The paper itself

Abstract

The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through multiple mechanisms that include extravascular compressive forces (tissue pressure), coronary perfusion pressure, myogenic, local metabolic, endothelial as well as neural and hormonal influences. While each of these determinants can have profound influence over myocardial perfusion, largely through effects on end-effector ion channels, these mechanisms collectively modulate coronary vascular resistance and act to ensure that the myocardial requirements for oxygen and substrates are adequately provided by the coronary circulation. The purpose of this series of Comprehensive Physiology is to highlight current knowledge regarding the physiologic regulation of coronary blood flow, with emphasis on functional anatomy and the interplay between the physical and biological determinants of myocardial oxygen delivery. © 2017 American Physiological Society. Compr Physiol 7:321-382, 2017.

Indexed as

Coronary CirculationCoronary VesselsEndothelium, VascularHomeostasisHormonesHumansIon ChannelsMyocardiumOxygen ConsumptionVascular ResistanceVasodilationHormonesIon Channels

Identifiers

PMID28333376
PMCPMC5966026
OpenAlexW2418215637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.