ArticleMolecular biology and evolution2017
Detection of Pathways Affected by Positive Selection in Primate Lineages Ancestral to Humans.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Longer-lived mammals exhibit greater evolutionary conservatism and epigenetic modification at cancer-associated loci.Nature communications · 2026Article
- Adaptive value of marginal populations: integrating selective signals, neutral processes and temporal scales.Heredity · 2026Article
- Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles.Annual review of genetics · 2025Review
- Identification of genetic signatures of positive selection in apes linked to life-history trait adaptations.Genes & genomics · 2025Article
- Degeneration of the Olfactory System in a Murid Rodent that Evolved Diurnalism.Molecular biology and evolution · 2024Article
- Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.The EMBO journal · 2023Article
- Correlated evolution of social organization and lifespan in mammals.Nature communications · 2023Article
- Comparative genomics uncovers the evolutionary history, demography, and molecular adaptations of South American canids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Anthropological Prosociality via Sub-Group Level Selection.Integrative psychological & behavioral science · 2022Article
- Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model.Molecular biology and evolution · 2022Article
- A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signalling.Frontiers in neuroscience · 2022Article
- Using singleton densities to detect recent selection inEvolution letters · 2021Article
- Modulation of bioelectric cues in the evolution of flying fishes.Current biology : CB · 2021Article
- Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals.BMC biology · 2021Article
- Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection.Molecular systems biology · 2021Article
- Current Progress in Evolutionary Comparative Genomics of Great Apes.Frontiers in genetics · 2021Review
- Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution.Frontiers in genetics · 2021Article
- Robust inference of positive selection on regulatory sequences in the human brain.Science advances · 2020Article
- Developmental constraint shaped genome evolution and erythrocyte loss in Antarctic fishes following paleoclimate change.PLoS genetics · 2020Article
- What can be learned by scanning the genome for molecular convergence in wild populations?Annals of the New York Academy of Sciences · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene set enrichment approaches have been increasingly successful in finding signals of recent polygenic selection in the human genome. In this study, we aim at detecting biological pathways affected by positive selection in more ancient human evolutionary history. Focusing on four branches of the primate tree that lead to modern humans, we tested all available protein coding gene trees of the Primates clade for signals of adaptation in these branches, using the likelihood-based branch site test of positive selection. The results of these locus-specific tests were then used as input for a gene set enrichment test, where whole pathways are globally scored for a signal of positive selection, instead of focusing only on outlier "significant" genes. We identified signals of positive selection in several pathways that are mainly involved in immune response, sensory perception, metabolism, and energy production. These pathway-level results are highly significant, even though there is no functional enrichment when only focusing on top scoring genes. Interestingly, several gene sets are found significant at multiple levels in the phylogeny, but different genes are responsible for the selection signal in the different branches. This suggests that the same function has been optimized in different ways at different times in primate evolution.
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