ArticleMolecular biology and evolution2017
Probing the Evolutionary History of Human Bitter Taste Receptor Pseudogenes by Restoring Their Function.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Bitter 2,5-Diketopiperazines From Cocoa Activate Human Bitter Taste Receptors.Molecular nutrition & food research · 2026Article
- Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors.Annals of the New York Academy of Sciences · 2026Article
- Bitter taste receptors.Chemical senses · 2025Review
- The Remarkable Diversity of Vertebrate Bitter Taste Receptors: Recent Advances in Genomic and Functional Studies.International journal of molecular sciences · 2024Review
- Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor.Molecular nutrition & food research · 2023Article
- Noninsect-Based Diet Leads to Structural and Functional Changes of Acidic Chitinase in Carnivora.Molecular biology and evolution · 2022Article
- Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ionsProceedings. Biological sciences · 2021Article
- Taste Perception of Antidesma bunius Fruit and Its Relationships to Bitter Taste Receptor Gene Haplotypes.Chemical senses · 2018Article
- Article
- Lineage-specific evolution of bitter taste receptor genes in the giant and red pandas implies dietary adaptation.Integrative zoology · 2018Article
- Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.Frontiers in molecular biosciences · 2018Article
- A Matter of Taste: Lineage-Specific Loss of Function of Taste Receptor Genes in Vertebrates.Frontiers in molecular biosciences · 2017Review
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Authors and funding
5 authors.
Funding
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Abstract
Lineage-specific gene losses can be driven by selection or environmental adaptations. However, a lack of studies on the original function of species-specific pseudogenes leaves a gap in our understanding of their role in evolutionary histories. Pseudogenes are of particular relevance for taste perception genes, which encode for receptors that confer the ability to both identify nutritionally valuable substances and avoid potentially harmful substances. To explore the role of bitter taste pseudogenization events in human origins, we restored the open reading frames of the three human-specific pseudogenes and synthesized the reconstructed functional hTAS2R2, hTAS2R62 and hTAS2R64 receptors. We have identified ligands that differentially activate the human and chimpanzee forms of these receptors and several other human functional TAS2Rs. We show that these receptors are narrowly tuned, suggesting that bitter-taste sensitivities evolved independently in different species, and that these pseudogenization events occurred because of functional redundancy. The restoration of function of lineage-specific pseudogenes can aid in the reconstruction of their evolutionary history, and in understanding the forces that led to their pseudogenization.
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