ArticleMolecular biology and evolution2017
The Role of DAF-21/Hsp90 in Mouth-Form Plasticity in Pristionchus pacificus.
Article in Molecular biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Biosynthesis of modular signaling molecules requires functional diversification of carboxylesterases in Pristionchus pacificus.Communications biology · 2025Article
- Developmental transcriptomics inGenome research · 2025Article
- Evolution of lateralized gustation in nematodes.eLife · 2025Article
- EBAX-1/ZSWIM8 destabilizes miRNAs, resulting in transgenerational inheritance of a predatory trait.Science advances · 2025Article
- Genetic regulators of a resource polyphenism interact to couple predatory morphology and behaviour.Proceedings. Biological sciences · 2024Article
- A histone demethylase links the loss of plasticity to nongenetic inheritance and morphological change.Nature communications · 2023Article
- Co-option of an Astacin Metalloprotease Is Associated with an Evolutionarily Novel Feeding Morphology in a Predatory Nematode.Molecular biology and evolution · 2023Article
- A Mediator subunit imparts robustness to a polyphenism decision.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Influence of environmental temperature on mouth-form plasticity in Pristionchus pacificus acts through daf-11-dependent cGMP signaling.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2023Article
- Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus.Genetics · 2021Article
- Polyphenism of a Novel Trait Integrated Rapidly Evolving Genes into Ancestrally Plastic Networks.Molecular biology and evolution · 2021Article
- Geometric morphometrics of microscopic animals as exemplified by model nematodes.Nature protocols · 2020Article
- Article
- Conserved nuclear hormone receptors controlling a novel plastic trait target fast-evolving genes expressed in a single cell.PLoS genetics · 2020Article
- Crowdsourcing and the feasibility of manual gene annotation: A pilot study in the nematode Pristionchus pacificus.Scientific reports · 2019Article
- Polyphenism - A Window Into Gene-Environment Interactions and Phenotypic Plasticity.Frontiers in genetics · 2019Review
- The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease.International journal of molecular sciences · 2018Review
- On the Reciprocally Causal and Constructive Nature of Developmental Plasticity and Robustness.Frontiers in genetics · 2018Review
- Developmental Plasticity and Robustness of a Nematode Mouth-Form Polyphenism.Frontiers in genetics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenotypic plasticity is increasingly recognized to facilitate adaptive change in plants and animals, including insects, nematodes, and vertebrates. Plasticity can occur as continuous or discrete (polyphenisms) variation. In social insects, for example, in ants, some species have workers of distinct size classes while in other closely related species variation in size may be continuous. Despite the abundance of examples in nature, how discrete morphs are specified remains currently unknown. In theory, polyphenisms might require robustness, whereby the distribution of morphologies would be limited by the same mechanisms that execute buffering from stochastic perturbations, a function attributed to heat-shock proteins of the Hsp90 family. However, this possibility has never been directly tested because plasticity and robustness are considered to represent opposite evolutionary principles. Here, we used a polyphenism of feeding structures in the nematode Pristionchus pacificus to test the relationship between robustness and plasticity using geometric morphometrics of 20 mouth-form landmarks. We show that reducing heat-shock protein activity, which reduces developmental robustness, increases the range of mouth-form morphologies. Specifically, elevated temperature led to a shift within morphospace, pharmacological inhibition of all Hsp90 genes using radicicol treatment increased shape variability in both mouth-forms, and CRISPR/Cas9-induced Ppa-daf-21/Hsp90 knockout had a combined effect. Thus, Hsp90 canalizes the morphologies of plastic traits resulting in discrete polyphenism of mouth-forms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.