ArticleScientific reports2017
Cheetahs have a stronger constitutive innate immunity than leopards.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Boid inclusion body disease iniScience · 2026Article
- Epigenetic Changes Associated With a Phenotypic Transition in Namibian Cheetahs.Molecular ecology · 2026Article
- Unraveling genome- and immunome-wide genetic diversity in modern and historical Jaguars.Genome biology · 2025Article
- Life-history stage influences immune investment and oxidative stress in response to environmental heterogeneity in Antarctic fur seals.Communications biology · 2024Article
- Diversity of selected toll-like receptor genes in cheetahs (Acinonyx jubatus) and African leopards (Panthera pardus pardus).Scientific reports · 2024Article
- Could care giving have altered the evolution of human immune strategies?Evolution, medicine, and public health · 2024Article
- Evolutionary trade-off between innate and acquired immune defences in birds.Frontiers in zoology · 2023Article
- Comparative genomics of the Leukocyte Receptor Complex in carnivores.Frontiers in immunology · 2023Article
- Ecoimmunology in the field: Measuring multiple dimensions of immune function with minimally invasive, field-adapted techniques.American journal of human biology : the official journal of the Human Biology Council · 2022Review
- Genomic analyses show extremely perilous conservation status of African and Asiatic cheetahs (Acinonyx jubatus).Molecular ecology · 2022Article
- First Steps towards the Development of Epigenetic Biomarkers in Female Cheetahs (Life (Basel, Switzerland) · 2022Article
- Some Peculiarities of Anthrax Epidemiology in Herbivorous and Carnivorous Animals.Life (Basel, Switzerland) · 2022Review
- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
- The application of allostasis and allostatic load in animal species: A scoping review.PloS one · 2022Article
- Understanding the Role of Semiochemicals on the Reproductive Behaviour of Cheetahs (Animals : an open access journal from MDPI · 2021Review
- Noninvasively measured immune responses reflect current parasite infections in a wild carnivore and are linked to longevity.Ecology and evolution · 2021Article
- Molecular analysis suggests that Namibian cheetahs (Acinonyx jubatus) are definitive hosts of a so far undescribed Besnoitia species.Parasites & vectors · 2021Article
- Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world.Conservation physiology · 2021Article
- GPS Telemetry Reveals a Zebra With Anthrax as Putative Cause of Death for Three Cheetahs in the Namib Desert.Frontiers in veterinary science · 2021Article
- Species-specific differences in Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti seroprevalence in Namibian wildlife.Parasites & vectors · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a textbook case for the importance of genetics in conservation, absence of genetic variability at the major histocompatibility complex (MHC) is thought to endanger species viability, since it is considered crucial for pathogen resistance. An alternative view of the immune system inspired by life history theory posits that a strong response should evolve in other components of the immune system if there is little variation in the MHC. In contrast to the leopard (Panthera pardus), the cheetah (Acinonyx jubatus) has a relatively low genetic variability at the MHC, yet free-ranging cheetahs are healthy. By comparing the functional competence of the humoral immune system of both species in sympatric populations in Namibia, we demonstrate that cheetahs have a higher constitutive innate but lower induced innate and adaptive immunity than leopards. We conclude (1) immunocompetence of cheetahs is higher than previously thought; (2) studying both innate and adaptive components of immune systems will enrich conservation science.
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