Evidence map›Paper›PMID 28333125›Full record

ArticleScientific reports2017

CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions.

Yi Feng, Peng Cui, Xiaowei Lu, Brian Hsueh, Fredrik Möller Billig, Livia Zarnescu Yanez, Raju Tomer, Derek Boerboom, Peter Carmeliet, Karl Deisseroth and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 108 citations in OpenAlex.

  1. Article
  2. Quantitative Parameters of Contrast-Enhanced Ultrasonography (CEUS) Monitoring Ovarian Hemodynamics in Rats.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
  3. Ovarian Matrisome Dynamics and αvβ3-Mediated Regulation in Early Follicular Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  7. ReducediScience · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Yi FengDepartments of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Peng CuiDepartments of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Xiaowei LuDepartments of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Brian HsuehDepartment of Bioengineering, Howard Hughes Medical Institute, CNC Program, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Fredrik Möller BilligDepartments of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Livia Zarnescu YanezDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Raju TomerDepartment of Bioengineering, Howard Hughes Medical Institute, CNC Program, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Derek BoerboomCentre de Recherche en Reproduction Animale, Université de Montréal, St-Hyacinthe, Québec, Canada.
Peter CarmelietLaboratory of Angioenesis and Vascular Metabolism, Vesalius Research Center, VIB and Department of Oncology, University of Leuven, Leuven, Belgium.
Karl DeisserothDepartment of Bioengineering, Howard Hughes Medical Institute, CNC Program, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Aaron J W HsuehDepartments of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
Stanford University · USHoward Hughes Medical Institute · USKU Leuven · BEUniversité de Montréal · CA

Funding

Stanford University Center for Reproductive and Stem Cell biologyU54HD068158 · NICHD · STANFORD UNIVERSITY · PI HSUEH, AARON · 2011 to 2013
$5.0M
Stanford University Center for Reproductive and Stem Cell biologyP50HD068158 · NICHD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2014 to 2015
$3.3M
CIHR MOP-102508NICHD NIH HHS P50 HD068158NICHD NIH HHS U54 HD068158
6 · The paper itself

Abstract

Optimal distribution of heterogeneous organelles and cell types within an organ is essential for physiological processes. Unique for the ovary, hormonally regulated folliculogenesis, ovulation, luteal formation/regression and associated vasculature changes lead to tissue remodeling during each reproductive cycle. Using the CLARITY approach and marker immunostaining, we identified individual follicles and corpora lutea in intact ovaries. Monitoring lifetime changes in follicle populations showed age-dependent decreases in total follicles and percentages of advanced follicles. Follicle development from primordial to preovulatory stage was characterized by 3 × 10

Indexed as

Imaging, Three-DimensionalAnimalsAxitinibCorpus LuteumFemaleFluorescent Antibody TechniqueImidazolesIndazolesMiceMicrovesselsMutationOvarian FollicleOvaryPromoter Regions, GeneticProtein Kinase InhibitorsReceptors, Vascular Endothelial Growth FactorAxitinibImidazolesIndazolesProtein Kinase InhibitorsReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor A

Identifiers

PMID28333125
PMCPMC5363086
OpenAlexW2600753645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.