ArticleNutrients2017
South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women.
Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Global prevalences of erythropoiesis-associated micronutrient deficiencies (iron, folate, and vitamin BAnnals of medicine · 2025Pooled it
- DNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.BMC genomics · 2022Pooled it
- B vitamins and cardiovascular health: mechanisms, clinical evidence, and precision prevention strategies.Nutrition & metabolism · 2026Review
- Article
- Association of Vitamin B12 and Vitamin D Levels with Glycemic Control in Patients with Type 2 Diabetes Mellitus.International journal of preventive medicine · 2025Article
- Assessing anemia burden and multifactorial contributors among pregnant women in Gujarat: a cross-sectional study integrating biochemical, nutritional, and geographic disparities.Frontiers in global women's health · 2025Article
- Impact of metformin treatment on cobalamin status in persons with type 2 diabetes.Nutrition reviews · 2024Review
- B12 Deficiency is the Commonest Cause of Anaemia During Pregnancy in Northern India: Study from a Tertiary Care Institute.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024Article
- A Case-Control Study of the MTHFR C665T Gene Polymorphism on Macrocytic Anemia Among HIV-Infected Patients Receiving Zidovudine.Journal of multidisciplinary healthcare · 2022Article
- Vitamin BCurrent medical science · 2020Article
- The Effects of Vegetarian and Vegan Diet during Pregnancy on the Health of Mothers and Offspring.Nutrients · 2019Review
- High incidence of maternal vitamin BWorld journal of pediatrics : WJP · 2018Article
- Prevalence of Vitamin B12 Deficiency and Its Associated Risk Factors among Pregnant Women of Rural South India: A Community-based Cross-sectional Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
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Authors and funding
6 authors at 1 institution in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin B12 (B12) adequacy during pregnancy is crucial for maternal health and optimal fetal development; however, suboptimal B12 status has been reported in pregnant Canadian women. Methylmalonic acid (MMA) is a sensitive indicator of B12 status. Since few studies have measured MMA during pregnancy in Canadian women, the objective of this study was to evaluate B12 status in pregnant women living in Metro Vancouver, using both plasma total B12 and MMA. We recruited a convenience sample of 320 pregnant women between 20 and 35 gestational weeks from local healthcare facilities. Plasma total B12 concentrations indicative of deficiency (<148 pmol/L) and suboptimal B12 status (148-220 pmol/L) were found in 18% and 33% of the women, respectively. Normal plasma MMA concentration (<210 nmol/L) was observed in 82% of all women. Gestational age was a strong predictor of plasma total B12 and MMA concentration, and South Asian ethnicity of B-12 deficiency and MMA concentrations. Overall, there was a high discrepancy between the prevalence of B12 inadequacy depending on the biomarker used. Independently, however, South Asian women were at particular risk for B12 deficiency, likely due to lower animal source food intake. Further study of this vulnerable group and performance testing of B12 biomarkers is warranted.
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