Evidence map›Paper›PMID 28332901›Full record

ArticleGut microbes2017

Regulation of humoral immunity by gut microbial products.

Myunghoo Kim, Chang H Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Microbiome and well-being: a meta-analysis.NPJ biofilms and microbiomes · 2025
    Pooled it
  2. Pooled it
  3. Combination of the ProbioticsFrontiers in immunology · 2021
    Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Metabolic interactions and growth dynamics ofFrontiers in microbiology · 2026
    Article
  9. Review
  10. The role ofFrontiers in immunology · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Myunghoo Kima Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology , Purdue University , West Lafayette , IN , USA.
Chang H Kima Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology , Purdue University , West Lafayette , IN , USA.

Funding

Homing of Functionally Distinct ILC SubsetsR01AI121302 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KIM, CHANG H · 2016 to 2020
$1.9M
Migration and function of Th17 cells in the gutR01AI080769 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2010 to 2013
$1.3M
NIAID NIH HHS R01 AI080769NIAID NIH HHS R01 AI121302
6 · The paper itself

Abstract

The intestinal tract provides ideal niches for several different microbial species, which are collectively called the gut microbiota. A key host immune effector that controls the microbiota and prevents mucosal infection is IgA. Gut microbiota-derived factors are largely classified into molecular pattern recognition receptor ligands and nutrient-derived metabolites including short-chain fatty acids and adenosine triphosphate. Along with host-derived factors such as retinoic acid, various cytokines and cytokine-like molecules, gut microbial products profoundly shape B cell responses. Gut microbial products can directly regulate B cell activation and differentiation. They can also indirectly affect B cells through epithelial cells, T cells, and myeloid cell subsets. We highlight the various direct and indirect mechanisms by which microbial products regulate humoral immunity.

Indexed as

Gastrointestinal MicrobiomeImmunity, HumoralAnimalsBacteriaB-LymphocytesEpithelial CellsFatty Acids, VolatileHumansIntestinesT-LymphocytesFatty Acids, VolatileB cellsGut microbiotahumoral immunityIgAshort-chain fatty acids

Identifiers

PMID28332901
PMCPMC5570419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.